Mark A. Feitelson

Hepatitis C Virus (eBook, PDF)

From Laboratory to Clinic

• Format: PDF

Produktbeschreibung

Hepatitis C infects 170 million people worldwide, and has been labelled the 'silent epidemic' as a result of its concealed attack on the liver. This multidisciplinary overview covers basic concepts related to the discovery of the virus, development of serological and nucleic acid tests to detect infection, the structure of the virus genome, generation of virus gene products, and proposed replication scheme. It then goes on to introduce the epidemiology, transmission, pathogenesis of infection, the development of hepatocellular carcinoma associated with chronic virus infection, and current strategies for treatment. The book then discusses advances in cell culture systems, animal models of infection, and emerging treatments and vaccine development. Through its coverage of basic science, clinical consequences, and methods of research, this integrated and accessible account will be of immense value to biomedical scientists and clinicians alike, and a useful introduction for all those studying the virus and its effects.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 28. März 2002
• Englisch
• ISBN-13: 9780511032073
• Artikelnr.: 38207608

Autorenporträt

Mark A. Feitelson, Ph.D. is currently Professor in the Department of Pathology, Anatomy and Cell Biology. He has a secondary appointment in the Department of Microbiology and Immunology and is a member of the Kimmel Cancer Center at Thomas Jefferson University. In addition, he is head of the Molecular Diagnostics Laboratory in Microbiology for Thomas Jefferson University Hospital. Prior to his transfer to Jefferson Medical College, Dr Feitelson trained with the nobel laureate Dr Baruch S. Blumberg at the Fox Chase Cancer Center. Dr Feitelson has been working on the biology and pathogenesis of hepatitis B for more than 20 years, and has recently started a similar research program in hepatitis C.

Inhaltsangabe

Preface
Part I. Basic Principles: 1. Background
2. The virus
3. Epidemiology and transmission
4. Natural history of infection
5. Pathogenesis of infection
6. HCV and hepatocellular carcinoma
7. Extrahepatic sites for hepatatis C
8. HCV and autoimmune diseases
9. Clinical aspects of the disease
10. Current therapeutic approaches
11. NS5A and interferon resistance
Part II. Recent Advances: 12. Propagation of virus in culture
13. Understanding the natural history of HCV
14. HCV animal models
15. Vaccine research
Part III. Experimental Approaches: 16. New systems to understand HCV biology
17. New antiviral screening assays
18. Antiviral gene therapy
Part IV. Protocols and Techniques: 19. Sample collection, preparation and storage
20. HCV RNA in blood and tissue samples
21. HCV RNA genotypes and quasispecies
22. Replication of HCV in tissue culture
23. NS3 protease, helicase and NTPase
24. Characterization of NS5B
Part V. Outstanding Questions and Emerging Areas for Investigation
References
Index.