HIV-Associated Neurocognitive Disorders (eBook, ePUB)

Redaktion: Hu, Guoku; Buch, Shilpa; Xiong, Huangui

• Format: ePub

Produktbeschreibung

HIV-Associated Neurocognitive Disorders: Molecular and Cellular Mechanisms and Clinical Manifestations is a comprehensive volume on the field of HIV-Associated Neurocognitive Disorders (HAND) as well as its associated comorbidities. Covering clinical manifestations as well as molecular and cellular mechanisms, this book discusses available macaque and rodent animal models of HAND, epigenetic regulation, and signaling pathways underlying symptoms. Chapters also cover prevention and therapeutic strategies, as well as diagnosis and biomarkers associated with disease outcomes. This volume is appropriate for basic research and clinical investigators working in the area of HIV-1 infection.

• Provides an in-depth exploration of the clinical manifestations of HAND and its comorbidities
• Includes detailed assessments of the molecular and cellular mechanisms underlying HAND symptoms
• Examines animal models for studying HAND, including macaque and rodent models
• Presents insights into epigenetic regulation and signaling pathways implicated in HAND
• Covers prevention, therapeutic strategies, and diagnostic approaches

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 525
• Erscheinungstermin: 21. Februar 2024
• Englisch
• ISBN-13: 9780323997454
• Artikelnr.: 70036857

Inhaltsangabe

1. An overview of the mechanisms of HIV-1 infection, latency, pathogenesis,
and eradication strategies from the CNS
2. Central Nervous System Complications of Human Immunodeficiency Virus
Infection
3. Health LIteracy in HIV-associated Neurocognitive Disorders
4. Neuroimaging insights into the CNS effects of HIV infection
5. Early and upstream subcellular organellar events associated with HAND
6. White matter loss and oligodendrocyte dysfunction in HAND
7. Pathogenesis of HIV-associated pain
8. Neuropathogenesis of HIV-associated neuropathic pain
9. Neuropathic Pain in HIV and the role of the Autophagy pathway
10. Host peripheral immune dynamics increase HIV-associated neurocognitive
disorders incidence and progression
11. The role of immunometabolism in HIV associated depression and cognitive
impairment
12. Role of extracellular viral regulatory proteins in neuropathogenesis
13. Role of inflammasomes in HIV-1 and drug abuse-mediated
neuroinflammation
14. The Contribution of Myeloid Cells to HIV Neuropathogenesis
15. Immunophilin ligands modulate phagocytosis and viral replication in
HIV-infected macrophages
16. Immunometabolic mechanisms of HIV-associated neurocognitive disorders
and traumatic brain injury: Commonalities and contrasts between chronic and
acute neurodegenerative pathologies
17. Endolysosome dysfunction in HAND
18. Evolving biomarkers for HIV-associated neurocognitive disorders (HAND)
19. Intracellular immunity against HIV infection
20. NeuroHIV and the Glymphatic System
21. The p75 neurotrophin receptor: emerging role in the pathogenesis of
mature synapses in Human Immunodeficiency Virus-Associated Neurocognitive
Disorders
22. The Role of HIV-Associated Neuroendocrine Dysfunction in HAND
23. Impact of SARS-CoV-2/COVID-19 on HIV-1-associated neurocognitive
disorders
24. Molecular mechanisms of dopaminergic transmission in NeuroHIV
25. The effect of substance misuse on HIV persistence in the CNS:
epidemiological, immunological, and molecular considerations
26. Extracellular vesicles in alcohol- and tobacco-induced neuroAIDS
27. NeuroHIV in the context of opioid use disorder: A complex and evolving
relationship
28. Impairment of cholesterol homeostasis induced by Nef-containing
extracellular vesicles as a factor in HAND pathogenesis
29. Long noncoding RNAs in immune response, viral infection, and opioid use
30. Using cross-species behavioral tools to determine mechanisms
contributing to HIV associated neurological disorders and comorbid
substance use
31. Therapeutic potential of Curcumin in treating HIV-1 associated
neurocognitive disorders
32. Targeting the Endocannabinoid System in HAND
33. Predicting the effectiveness of combination treatment of Dolutegravir
and Fluoxetine for Depressive disorders in HIV
34. ANTIRETROVIRAL THERAPY AND ITS CEREBRAL VASCULAR TOXICITY
35. Strategies for HIV-1 Elimination