Human Risk Assessment (eBook, PDF)

The Role Of Animal Selection And Extrapolation
Redaktion: Roloff, M V

• Format: PDF

Produktbeschreibung

This book explores the factors which are critical in the selection of an appropriate animal species for toxicology studies and the subsequent extrapolation of the data to humans. It provides some future directions for risk assessment activities at the Environmental Protection Agency.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 300
• Erscheinungstermin: 28. Oktober 2020
• Englisch
• ISBN-13: 9781000124507
• Artikelnr.: 60434909

Autorenporträt

Roloff\, M V

Inhaltsangabe

1. Animal selection and extrapolation - the problem defined Part I: Current
industrial practices and regulatory status of animal selection and
extrapolation 2. Current EPA perspectives on animal selection and
extrapolation 3. Current FDA perspectives on animal selection and
extrapolation 4. International perspectives on animal selection and
extrapolation 5. Opinions on animal selection for the assessment of
carcinogenicity Part 2: Use of physiological and toxicological data from
man and animals as aids in animal selection and extrapolation 6. Anatomical
and physiological considerations in species selections - animal comparisons
7. The role of diet and nutrition in safety evaluation of drugs and other
chemicals 8. The role of clinical pathology in the selection of animal
species 9. Species differences in toxic lesions Part 3: Metabolic and
pharmacokinetic considerations in species selection 10. Retrospective
evaluation of appropriate animal models based on metabolism studies in man
11. The role of studies of absorption, metabolism, distribution and
elimination in animal selection and extrapolation 12. Physiologically based
pharmacokinetics and methylene chloride cancer risk assessment
considerations 13. Route of exposure: An important consideration in animal
selection and the design of toxicity studies Part 4: Animal selection
considerations in carcinogenic and reproductive toxicity 14. The short-term
assays: The challenges and problems of adolescence 15. Testing procedures
to define carcinogens as human cancer risks 16. Risk assessment
considerations for the reproductive and developmental toxicity of
oestrogenic xenobiotics 17. Selection of animals for reproductive
toxicology studies: An evaluation of selected assumptions in reproductive
toxicity testing and risk assessment Part 5: Pharmacogenetic and human
monitoring considerations in animal selection 18. Pharmacogenetic
considerations in the selection of appropriate animal models in teratology
19. Pharmacogenetic differences between humans and laboratory animals:
Implications for modelling 20. Studies of cellular reaction to toxicity in
human cells and tissues: Extrapolation of animal data to man 21. Problems
and prospects in inter-species extrapolation Summary 22. Selection and
extrapolation - the task of implementation