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This book focuses on novel design and systems engineering approaches, including theories and best practices, for promoting a better integration of people and engineering systems. It covers a range of innovative topics related to: development of human-centered systems; interface design and human-computer interaction; usability and user experience; innovative materials in design and manufacturing; biomechanics and physical rehabilitation, as well as safety engineering and systems complexity. The book, which gathers selected papers presented at the 3rd International Conference on Human Systems Engineering and Design: Future Trends and Applications (IHSED 2020), held on September 22-24, 2020, at Juraj Dobrila University of Pula, in Pula, Croatia, provides researchers and practitioners with a snapshot of the state-of-the-art and current challenges in the field of human systems engineering and design.