Huntington's Disease (eBook, ePUB)

Pathogenic Mechanisms and Implications for Therapeutics
Redaktion: Yang M. D., Ph. D.; Thompson Ph. D., Leslie M.; Heiman, Myriam

• Format: ePub

Produktbeschreibung

Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical trial of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics, reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge testing of therapeutic strategies for HD. Chapters explore areas such as, normal huntingtin biology in brain development and function, genetic modifiers of HD in patients, molecular pathogenic mechanism in HD, and mechanisms underlying selective neuronal vulnerability

• Reviews the clinical course and genetics of HD
• Reviews the biology of human huntingtin and HD-relevant cell types
• Reviews the wide range of pathobiology associated with mutant huntingtin
• Reviews genetic studies of HD and how these studies are informing the development of new therapeutic approaches
• Reviews new tools and model systems for basic and translational research in HD, including new human-derived model systems, as well as systems biology and artificial intelligence-driven approaches
• Provides an overview of new therapeutic approaches and current clinical programs in HD

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 425
• Erscheinungstermin: 7. Februar 2024
• Englisch
• ISBN-13: 9780323956734
• Artikelnr.: 69939794

Inhaltsangabe

1. Huntington’s Disease: Clinical Features, Genetic Diagnosis, and Brain
Imaging Carlos Estevez-Fraga, Mitsuko Nakajima and Sarah J. Tabrizi 2.
Revolutionizing Clinical Research and Communication in Huntington’s
Disease: The Huntington’s Disease Integrated Staging System (HD-ISS)
Cristina Sampaio, Jeffrey D. Long, Alexandra Mansbach, Sarah J. Tabrizi,
Emily C. Gantman 3. Huntington’s Disease Genetics: Implications for
Pathogenesis Marcy E. Macdonald, Jong-Min Lee and James F. Gusella 4. The
Instability of the Huntington’s Disease CAG Repeat Mutation Vanessa C.
Wheeler, Joseph C. Stone, Thomas H. Massey and Ricardo Mouro Pinto 5.
Mechanisms of Somatic CAG -Repeat Expansions in Huntington’s Disease Amit
L. Deshmukh, Terence Gall-Duncan and Christopher E. Pearson 6. RNA-Mediated
Pathogenic Mechanisms in Huntington’s Disease Gillian P. Bates, Sandra
Fienko, Christian Landles and Aikaterini-Smaragdi Papadopoulou 7.
Huntingtin Protein-protein Interactions: From Biology to Therapeutic
Targets Eduardo Silva Ramos, Todd M. Greco, Ileana M. Cristea and Erich E.
Wanker 8. Repeat-Associated Non-AUG (RAN) Translation and Huntington’s
Disease: Pathology, Mechanistic and Therapeutic Perspectives Monica
Banez-Coronel, John Douglas Cleary and Laura P.W. Ranum 9. Proteostasis
Function and Dysfunction in Huntington’s Disease Juliana Abramovich, Korbin
Kleczko, Vincent Masto and Judith Frydman 10. Autophagy and Huntington’s
Disease Katherine R. Croce, Hilary Grosso Jasutkar and Ai Yamamoto 11. SUMO
Modification in Huntington’s Disease: Unraveling Complex Mechanisms for
Therapeutic Insights Charlene Smith, Joan S. Steffan and Leslie M. Thompson
12. Selective Vulnerability in Huntington’s Disease: From Excitotoxicity,
Mitochondrial Dysfunction, and Transcription Dysregulation to Therapeutic
Opportunity Jacob S. Deyell, Ravinder Gulia and Albert R. La Spada 13.
Pathophysiology of Synapses and Circuits in Huntington Disease Marja D.
Sepers, James Mackay and Lynn A. Raymond 14. The Role of Glial Pathology in
Huntington’s Disease Steven A. Goldman 15. Systems Biology Study of
Huntington’s Disease Leonardo E. Dionisio, Peter Langfelder, Jeffrey S.
Aaronson, Jim Rosinski and X. William Yang 16. Unbiased Genome-Wide
Approaches to Identify Vulnerability Factors in Huntington’s Disease
Suphinya Sathitloetsakun and Myriam Heiman 17. Striatal Neuronal Models of
Huntington’s Disease Via Direct Conversion: Modeling Age-dependent Disease
Phenotypes Young Mi Oh, Seong Won Lee and Andrew S. Yoo 18. Genetic Mouse
Models to Explore Huntington’s Disease Mechanisms and Therapeutic
Strategies Michelle Gray, Scott O. Zeitlin, Aida Moran-Reyna and Jeh-Ping
Liu 19. Huntington’s Disease: From Large Animal Models to HD Gene Therapy
Sen Yan, Xiao-Jiang Li and Shihua Li 20. Deep Learning and Deep Phenotyping
of HD iPSCs: Applications to Study Biology and Test Therapeutics Steven
Finkbeiner 21. The Promise of an Underappreciated Therapeutic Target: Sleep
and Circadian Rhythm Dysfunction in Huntington’s Disease Christopher S.
Colwell, Weiyi Tan and A. Jennifer Morton 22. Huntingtin Lowering
Therapeutics Neil Aronin, Miguel E. Sena-Esteves, Anastasia Khvorova,
Marian Difiglia and Michael Brodsky 23. Gene Editing for HD: Therapeutic
Prospects Richard Z. Chen and Thomas F. Vogt 24. Current Clinical Trials of
New Therapeutic Agents for Huntington’s Disease Blair R. Leavitt