K. D. Rainsford

Ibuprofen: Pharmacology, Therapeutics and Side Effects (eBook, PDF)

• Format: PDF

Produktbeschreibung

Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs.

This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.

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Produktdetails

• Verlag: Birkhäuser Basel
• Seitenzahl: 243
• Erscheinungstermin: 1. Februar 2013
• Englisch
• ISBN-13: 9783034804967
• Artikelnr.: 37680071

Inhaltsangabe

Introduction.- Biodisposition in relation to actions.- Mechanisms of inflammation and sites of action of NSAIDs.- Clinical efficacy.- Drug derivatives and formulations.- General safety profile.- Gastro-intestinal toxicity.- Cardiovascular safety.- Renal toxicity.- Hepatic toxicity.- Other adverse reactions.- Global assessment of adverse reactions & human toxicology.- Overall assessment.

Rezensionen

From the reviews: "This book is intended for a broad readership -- anyone interested in the properties, actions, and uses of ibuprofen. This book serves this aim very well ... . The book is of great value for anyone who wants to understand the historical development and clinical utility of a very popular nonsteroidal anti-inflammatory drug (NSAID) ... . This is an outstanding historical and factual account of ibuprofen, one of the most widely used analgesic/antipyretic/anti-inflammatory drugs today." (Thomas L. Pazdernik, Doody's Book Reviews, May, 2013)