Impact of Engineered Nanomaterials in Genomics and Epigenomics (eBook, PDF)

Redaktion: Sahu, Saura C.

• Format: PDF

Produktbeschreibung

Impact of Engineered Nanomaterials in Genomics and Epigenomics Overview of current research and technologies in nanomaterial science as applied to omics science at the single cell level Impact of Engineered Nanomaterials in Genomics and Epigenomics is a comprehensive and authoritative compilation of the genetic processes and instructions that specifically direct individual genes to turn on or off, focusing on the developing technologies of engineering nanomaterials and their role in cell engineering which have become important research tools for pharmaceutical, biological, medical, and toxicological studies. Combining state-of-the art information on the impact of engineered nanomaterials in genomics and epigenomics, from a range of internationally recognized investigators from around the world, this edited volume offers unique insights into the current trends and future directions of research in this scientific field. Impact of Engineered Nanomaterials in Genomics and Epigenomics includes detailed information on sample topics such as: * Impact of engineered nanomaterials in genomics and epigenomics, including adverse impact on glucose energy metabolism * Toxicogenomics, toxicoepigenomics, genotoxicity and epigenotoxicity, and mechanisms of toxicogenomics and toxicoepigenomics * Adverse effects of engineered nanomaterials on human environment and metabolomics pathways leading to ecological toxicity * Meta-analysis methods to identify genomic toxicity mechanisms of engineered nanomaterials and biological effects of engineered nanomaterial exposure * Artificial intelligence and machine learning of single-cell transcriptomics of engineered nanoparticles and trends in plant nano-interaction to mitigate abiotic stresses This comprehensive work is a valuable and excellent source of authoritative and up-to-date information for advanced students and researchers, toxicologists, the drug industry, risk assessors and regulators in academia, industry, and government, as well as for clinical scientists working in hospital and clinical environments.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 448
• Erscheinungstermin: 20. Mai 2023
• Englisch
• ISBN-13: 9781119896234
• Artikelnr.: 68134158

Autorenporträt

Saura C. Sahu, PhD, is a former Research Chemist with the Division of Toxicology at the Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition at the United States Food and Drug Administration.

Inhaltsangabe

Contents

List of Contributors xv

Preface xix

Acknowledgments xxi

1 Impact of Engineered Nanomaterials in Genomics and Epigenomics 1

Saura C. Sahu Contents

Nanotechnology: A Technological Advancement of the Twenty-First Century 1

Genomics and Epigenomics 1

Beneficial Impacts of Engineered Nanomaterials on Human Life 2

Potential Adverse Health Effects of Engineered Nanomaterials 2

Conclusions 3

References 3

2 Molecular Impacts of Advanced Nanomaterials at Genomic and Epigenomic Levels 5

Kamran Shekh, Rais A Ansari, Yadollah Omidi, and Saghir A. Shakil

Introduction 5

Classification of NMs 6

Absorption and Distribution of NMs 6

Major Adverse Effects of NMs 8

Known Cellular and Nuclear Uptake Mechanisms for Nanoparticles 10

Epigenetic Mechanisms and the Effect of NMs 11

DNA Methylation 12

Genetic and Genomic Effects of NMs 20

Conclusion 25

References 26

3 Endocrine Disruptors: Genetic, Epigenetic, and Related Pathways 41

Rais A. Ansari, Saleh Alfuraih, Kamran Shekh, Yadollah Omidi, Saleem Javed, and Saghir A. Shakil

Introduction 41

Toxic Effects of EDCs on Wildlife and Humans 47

Effects During Development 48

Delayed Effects 48

Transgenerational Effects 49

Identification of EDC: Methods 49

Genetic Pathways 50

Phosphorylation-Mediated Signaling Pathways of Nuclear Receptors and Other Transcription Factors: Link to EDC 53

ER-Signaling Pathways 53

Xenoandrogens and Metabolic Syndrome 54

AR Signaling Pathways 54

Mechanism of ED 55

Methylation and Gene Regulation 55

Role of Noncoding RNAs 59

Transgenerational Inheritance of Epigenetics Induced by EDCs 59

Anti-Thyroids 60

Organotin 62

Epigenetic Effects of Organotin 63

TCDD and Related Compounds 63

TCDD and Genetic Response 64

TCDD-Mediated Epigenetic Response 65

Conclusions 65

References 66

4 Nanoplastics in Agroecosystem and Phytotoxicity: An Evaluation of Cytogenotoxicity and Epigenetic Regulation 83

Piyoosh Kumar Babele and Ravi Kant Bhatia

Introduction 83

Fate and Behavior of NPs in Agroecosystem and Soil Environment 85

Uptake and Accumulation of NPs in Plants 87

NPs and Phytotoxicity 88

Can NPs Cause Cytogenotoxicity and Dysregulate Epigenetic Markers in Plants? 89

NPs and Epigenetic Regulation 91

Conclusion and Perspectives 92

References 93

5 Metal Oxide Nanoparticles and Graphene-Based Nanomaterials: Genotoxic, Oxidative, and Epigenetic Effects 99

Delia Cavallo, Pieranna Chiarella, Anna Maria Fresegna, Aureliano Ciervo, Valentina Del Frate, and Cinzia Lucia Ursini

Introduction 99

Physicochemical Properties of NMs and Toxicity 100

Mechanism of NM Genotoxicity 101

Epigenetic Effects of Nanomaterials 102

Studies on Genotoxic and Oxidative Effects of Metal Oxides and Graphene-Based Nanomaterials 104

Graphene-Based NMs 120

Studies on Epigenetic Effects of Metal Oxides and Graphene-Based Nanomaterials 123

Studies on Workers - Genotoxic and Oxidative Effects of Occupational Exposure to Metal Oxides Nanoparticles, SiO2 NPs, and Graphene-Based Nanomaterials 127

Conclusions 132

References 132

6 Epigenotoxicity of Titanium Dioxide Nanoparticles 145

Carlos Wells, Marta Pogri