Inflammation and Allergy Drug Design (eBook, PDF)

Redaktion: Izuhara, K.; Wills-Karp, Marsha; Holgate, Stephen T.

• Format: PDF

Produktbeschreibung

Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit. Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate students and clinicians with a basic understanding of allergic diseases in the respiratory tract.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 328
• Erscheinungstermin: 20. Juli 2011
• Englisch
• ISBN-13: 9781444346664
• Artikelnr.: 38454868

Autorenporträt

Edited by K. Izuhara, MD, PhD, Saga Medical School, Nabeshima, Japan Stephen T. Holgate, MD, DSc, FRCP, Southampton General Hospital, UK Marsha Wills-Karp, PhD, Children's Hospital Medical Center, Cincinnati, USA

Inhaltsangabe

Contributors
vii Preface
xiii Part I: Cells contributing to the pathogenesis of allergic diseases in the respiratory tract 1 Novel anti-infl ammatory drugs based on targeting lung dendritic cells and airway epithelial cells
3 Bart N. Lambrecht
Maud Plantinga
Monique Willart
and Hamida Hammad 2 Role of Th2 cells in the allergic diathesis
15 Marsha Wills-Karp 3 Importance of Th17- and Th1-associated responses for the development of asthma
27 Tomohiro Yoshimoto
Hiroko Tsutsui
and Kenji Nakanishi 4 Regulatory T cells
39 Chris Corrigan and Kimuli Ryanna 5 A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders
59 Hiroshi Watarai
Michishige Harada
Mayumi Tamari
and Masaru Taniguchi 6 Regulatory roles of B cells in allergy and infl ammation
67 Kiyoshi Takatsu
Masashi Ikutani and Yoshinori Nagai 7 Mast cells
79 Mindy Tsai and Stephen J. Galli 8 Eosinophils
107 Nancy A. Lee
Mark V. Dahl
Elizabeth A. Jacobsen
and Sergei I. Ochkur 9 Basophils in infl ammation and allergy drug design
123 Donald MacGlashan
Jr. 10 Epithelial cells
139 Tillie-Louise Hackett
Stephanie Warner
Dorota Stefanowicz
and Darryl Knight 11 Fibroblasts
149 Alastair G. Stewart
Lilian Soon
and Michael Schuliga 12 Airway smooth muscle cells
163 Andrew J. Halayko and Pawan Sharma Part II: Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract 13 Interleukin 4
interleukin 13
and interleukin 9
175 Kenji Izuhara
Shoichiro Ohta
Hiroshi Shiraishi
and Shoichi Suzuki 14 Interleukin 3
interleukin 5
and granulocyte-macrophage colony-stimulating factor
187 Alba Llop-Guevara
Josip Marcinko
Ramzi Fattouh
and Manel Jordana 15 Interleukin 15
interleukin 17
and interleukin 25
197 Hiroshi Nakajima and Itsuo Iwamoto 16 Thymic stromal lymphopoietin
205 Kazuhiko Arima and Yong-Jun Liu 17 Interleukin 10
215 Whitney W. Stevens
Larry Borish
and John W. Steinke 18 Tumor necrosis factor alpha
225 Christopher Brightling
Latifa Chachi
Dhan Desai
and Yassine Amrani 19 Profi brotic and angiogenic factors in asthma
237 Neville Berkman and Francesca Levi-Schaffer 20 Chemokines
253 Luis M. Teran and Juan R. Velazquez 21 Epithelial growth factors
263 Yasuhiro Gon and Shu Hashimoto Part III: Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract 22 Prostanoids
273 Sarah A. Maher
Deborah L. Clarke
and Maria G. Belvisi 23 Leukotrienes
285 Katsuhide Okunishi and Marc Peters-Golden 24 Proteases in allergy
297 Keisuke Oboki and Hirohisa Saito 25 Toll-like receptors
307 Jessica L. Allen
Aurelien Trompette
and Christopher L. Karp Index
317