Robert F. Phalen

Inhalation Studies (eBook, PDF)

Foundations and Techniques

• Format: PDF

Produktbeschreibung

This significantly updated and expanded new edition presents the scientific foundations of inhalation research essential to the design and conduct of toxicologic studies. It explores the full range of numerous scientific developments in the field, including recent advances in biology and the rapidly increasing global concerns and studies on particulate air pollution. Key topics in the "Second Edition" include:

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 288
• Erscheinungstermin: 22. Oktober 2008
• Englisch
• ISBN-13: 9781420003260
• Artikelnr.: 42765686

Autorenporträt

ROBERT PHALEN Ph.D., co-directs the Air Pollution Health Effects Laboratory at the University of California, Irvine (UCI). He also holds two academic appointments in the College of Health Sciences at UCI: Professor in the Department of Community and Environmental Medicine; and Professor in the Department of Medicine's Center for Occupational and Environmental Health. He has served as Chair of both the UCI Institutional Review Board (for Human Studies) and the Institutional Animal Care and Use Committee. He is currently a member of the United States Environmental Protection Agency's Clean Air Scientific Advisory Committee-Particulate Material, and he is a member of 11 professional scientific associations/societies. In 1971, he obtained a Ph.D. in biophysics, with specialization in inhalation toxicology, from the University of Rochester (in Rochester, NY). His postdoctoral research was conducted at the Inhalation Toxicology Research Institute (now the Lovelace Respiratory Research Institute) in Albuquerque, NM. In 1972, Dr. Phalen joined the then College of Medicine at UCI to establish the Air Pollution Health Effects Laboratory, which still conducts studies relating to the toxicology of air pollutants, and trains graduate students and physicians in inhalation toxicology. His research is in several areas including: predicting doses from inhaled particles; health effects of inhaled air pollutants; and applied aerosol physics. He has published over 100 scientific papers, and authored and/or edited four previous books on aerosol inhalation topics.

Inhaltsangabe

1. Aerosols and Gases. Introduction. Direct Observation of Aerosol
Particles. Cigarette Smoke: A Familiar Aerosol System. Particle Size. Size
Distributions. Aerosol Properties. Aerosol Dynamics. Particle Size and
Toxicity. Properties of Gases. 2.The Respiratory Tract. Introduction.
Postnatal Development. Compartments. Gross Anatomy. Cells and Tissues.
Ventilation. Deposition of Inhaled Particles. Uptake of Inhaled Gases.
Defenses. 3. Establishing and Controlling Exposures. Introduction. Cleaning
and Conditioning. Throughput Air. Aerosol Generation. Gas Generation. Mixed
Aerosols and Gases. Principles for Stabilizing the Exposure Atmosphere. 4.
Characterizing Exposures. Introduction. The Breathing Zone. What should be
Measured? Instrumentation. Eliminating Measurement Interferences. Sampling
Protocols. 5. Methods for Exposing Subjects. Introduction. Basic Types of
Exposure Systems. Aging the Atmosphere. Ammonia as a Contaminant.
Determination of the Inhaled Dose. Ethical Responsibilities of the
Investigators. 6 Testing for Toxicity. Introduction. Qantitation.
Anatomical Considerations. Morphometry. Pulmonary Function. Other
Endpoints. Controls. Batteries of Endpoints. 7. Experimental Designs.
Introduction. Basic Statistical Considerations. Examples of Common Designs.
Multicomponent Atmospheres. 8. Facilities and Support Considerations.
Introduction. Facilities Components. Facilities Location. 9. Animal Models.
Introduction. Extrapolation from Laboratory Animals to Humans. Comparative
Dose Distribution. Comparative Physiology and Anatomy. Common Laboratory
Animal Models. 10. Regulations and Guidelines. Introduction. Guidelines vs.
Regulations. Protection of Laboratory Personnel. Protection of Research
Subjects. Inhalation Toxicity Testing Guidelines.