Inhibitors of Molecular Chaperones as Therapeutic Agents (eBook, PDF)

Redaktion: Machajewski, Timothy D; Gao, Zhenhai

• Format: PDF

Produktbeschreibung

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry.

Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text is an essential treatise for researchers working in academia and industry.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 352
• Erscheinungstermin: 23. Oktober 2013
• Englisch
• ISBN-13: 9781849739689
• Artikelnr.: 44764279

Inhaltsangabe

Section I Structure and Function: Conformational Dynamics, Structure and Functional Interactions of Hsp90 Chaperones
Structural Basis of Hsp90 Function
Structure and Function of Hsp70 - TBD
Exploiting the Dependency of Cancer Cells on Molecular Chaperones
Section II Small Molecule Inhibitors
Discovery of BIIB028
Discovery of STA-9090
Discovery of Serenex Hsp90 Inhibitor
Discovery of NVP-AUY922
Discovery of NVP-HSP990
Inhibitors of Hsp90 C-Terminal Domain
Hsp70 Inhibitors
Section III Clinical Perspectives
Clinical Development of Hsp90 Inhibitors as Anti-Cancer Agents
Hsp90 as a Potential Anti-Malarial Agent
Biomarker Development and Indication Selection
Other Disease Indications