Interferon: The 50th Anniversary (eBook, PDF)

Redaktion: Pitha, Paula M.

• Format: PDF

Produktbeschreibung

A vital text for researchers and clinicians in the fields of virology and oncology alike, this book is a comprehensive guide to one of medicine's most important tools that covers the most recent research. Important insights have been made in recent months that are challenging the accepted concept of the critical role of dsRNA in IFN induction. Recent work with genetically modified mice seems to confirm the original idea that interferon is the first cellular defense against viral infection.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 392
• Erscheinungstermin: 29. August 2007
• Englisch
• ISBN-13: 9783540713296
• Artikelnr.: 37368396

Autorenporträt

Paula M. Pitha, Johns Hopkins School of Medicine, Baltimore, MD, USA

Inhaltsangabe

Refletions.- How to Chase a Red Herring and Come up with a Smallmouth Bass.- Interferon Research BC (Before Cloning).- Purification and Cloning of Interferon Alpha.- Interferons and Their Signaling Pathways.- Type I Interferon: The Ever Unfolding Story.- The Receptor of the Type I Interferon Family.- IFN-?: Recent Advances in Understanding Regulation of Expression, Biological Functions, and Clinical Applications.- Cell Type-Specific Signaling in Response to Interferon-?.- Interferon Research: Impact on Understanding Transcriptional Control.- Recognition of Pathogens, Molecular Mechanism of Interferon Beta Induction.- TLR-Mediated Activation of Type I IFN During Antiviral Immune Responses: Fighting the Battle to Win the War.- Regulation of Antiviral Innate Immune Responses by RIG-I Family of RNA Helicases.- Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids.- Interferon-Induced Genes.- The Interferon-Stimulated Genes: Targets of Direct Signaling by Interferons, Double-Stranded RNA, and Viruses.- Structure and Function of the Protein Kinase R.- Virus Defense.- Viral Regulation and Evasion of the Host Response.- Pathogenic Viruses: Smart Manipulators of the Interferon System.- Role of Interferon in Viral Infection and Autoimmunity.- Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator.- Type I Interferon in Systemic Lupus Erythematosus.

Rezensionen

From the reviews:

"This compilation commemorates the 50th anniversary of the discovery of the first cytokine, interferon (IFN), by Isaacs and Lindermann ... . The editor has succeeded in compiling a small book that should satisfy readers interested in the history of IFN as well as those who want a convenient overview of the current status of the field. The book is written for scientists and, in particular, serious students of 'interferonolgy' ... . This is a nice addition to the many compilations on IFN ... ." (Patricia Fitzgerald-Bocarsly, Doody's Review Service, July, 2008)