Literature Review from the year 2018 in the subject Medicine - Alternative Medicine, grade: A, , course: Project, language: English, abstract: Background:There is increasing awareness of the use of Traditional medicine in today’s medical practices. This is a known fact that over 80% of the world population depends on herbal medicines and product for healthy living. The disappointment appears due to adulteration in the drugs, which is critical side for herbal manufacturers. Hence there is a need to develop validation techniques to prevent health, consumer’s faith as also for economic productivity. Medhya Rasayanas are a group of medicinal plants described in Ayurveda (Indian system of medicine) with multi-fold benefits, specifically to improve memory and intellect by Prabhava (specific action). Medha means intellect / retention and Rasayana means therapeutic procedure that on regular practice will boost nourishment, health, memory, intellect and immunity. Objective: To increase the awareness of use of medhyarasayan plants in nuerological disorders by giving light of research updates. Method: The research updates of Four Medhyarasayan plant spp namely Withania somnifera, Bacopa monnerie, Nardostachys jatamansi , Centell asiatica is mentioned in the present review covering the preclinical research aspact as also with mentioning their active principals. Results and Conclusion: The present review deals with a study of modern techniques/bioassays useful in validation of some Medhyarasayan plants. On the other hand, they are beneficial to understand metabolomics, physiology, biochemistry and proteomics of living being and also play a vital role in drug discovery.