Introduction to Bioinformatics (eBook, PDF)

A Theoretical And Practical Approach
Redaktion: Krawetz, Stephen A.; Womble, David D.

• Format: PDF

Produktbeschreibung

The genomic revolution that has spawned microarrays and high throughput technologies has produced vast amounts of complex biological data that require integration and multidimensional analysis. In Introduction to Bioinformatics: A Theoretical and Practical Approach, leading researchers and experts introduce the key biological, mathematical, statistical, and computer concepts and tools necessary for physical and life scientists to understand and analyze these data. For physical and computer scientists, the book provides a sound biological framework for understanding the questions a life scientist would ask in the context of currently available computational tools. Here, the basic cellular structure and the biological decoding of the genome, the long-range regulation of the genome, the in silico detection of the elements that impact long-range control, and the molecular genetic basis of disease as a consequence of replication are explained. Reviews of clinical human genetics, the various clinical databases, and pertinent issues in population genetics complete this tutorial. For life scientists, a complete discussion of the UNIX operating system, which is commonly used to support advanced computational tools, offers biologists graphical-user-interface comfort in a command-line environment, plus an understanding of the installation and management of UNIX-based software tools. It is in the applications sections that the book provides a common meeting ground for life and physical scientists. Here they will find examples of the management and analysis of DNA sequencing projects, the modeling of DNA as a statistical series of patterns, various methods of pattern discovery, protein visualization, and the use of multiple sequence alignment to infer both functional and structural biological relationships. Cross-disciplinary and highly instructive, Introduction to Bioinformatics: A Theoretical and Practical Approach offers life, mathematical, computer,and statistical scientists an integrated foundation for using today's many new computational advances to elucidate the nuances of both genetic code and integrated biological systems.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Humana Press
• Seitenzahl: 746
• Erscheinungstermin: 31. Januar 2003
• Englisch
• ISBN-13: 9781592593354
• Artikelnr.: 43982344

Autorenporträt

Wayne State University School of Medicine, Detroit, MI

Inhaltsangabe

Part I. Biochemistry, Cell, and Molecular BiologyA. The CellNucleic Acids and Proteins: Modern Linguistics for the Genomics and Bioinformatics EraBradley C. HymanStructure and Function of Cell OrganellesJon HolyCell SignalingDaniel A. RappoleeB. Transcription and TranslationDNA Replication, Repair, and RecombinationLinda B. BloomTranscription, RNA Processing, and TranslationThomas P. Yang and Thomas W. O'BrienPart II. Molecular GeneticsA. GenomicsEpigenetic Mechanisms Regulating Gene ExpressionJohn R. McCarreyGene Families and EvolutionBen F. KoopRepetitive DNA: Detection, Annotation, and AnalysisJerzy JurkaMolecular Genetics of Disease and the Human Genome ProjectParomita Deb-Rinker and Stephen W. SchererB. Clinical Human GeneticsHeredityC. A. RuparThe Clinical Genetics DatabasesPeter J. BridgePopulation GeneticsJill S. Barnholtz-SloanPart III. The UNIX Operating SystemA. Basics and InstallationIntroduction to UNIX for BiologistsDavid D. WombleInstallation of the Sun Solaris(TM) Operating EnvironmentBryon CampbellSun System AdministrationBryon CampbellB. Managing Bioinformatics ToolsInstalling Bioinformatics Software in a Server-Based Computing EnvironmentBrian FristenskyManagement of a Server-Based Bioinformatics ResourceBrian FristenskyC. Command Line Sequence AnalysisGCG File ManagementSittichoke SaisanitGCG Sequence AnalysisSittichoke SaisanitPart IV. Computer ApplicationsA. Management and Analysis of DNA Sequencing Projects and SequencesManaging Sequencing Projects in the GAP4 EnvironmentRodger Staden, David P. Judge, and James K. BonfieldOLIGO Primer Analysis SoftwareJohn D. Offerman and WojciechRychlikStatistical Modeling of DNA Sequences and PatternsGautam B. SinghStatistical Mining of the Matrix Attachment Regions in Genomic SequencesGautam B. SinghAnalyzing Sequences Using the Staden Package and EMBOSSRodger Staden, David P. Judge, and James K. BonfieldB. The Genome Database: Analysis and Similarity SearchingEnsembl: An Open-Source Software Tool for Large-Scale Genome AnalysisJames W. Stalker and Anthony V. CoxThe PIR for Functional Genomics and ProteomicsCathy H. WuSequence Similarity and Database SearchingDavid S. WishartGCG Database SearchingDavid J. HeardC. Identifying Functional and Structural Sequence ElementsPattern Discovery: Methods and SoftwareBrona Brejová, Tomás Vinar, and Ming LiThe Role of Transcription Factor Binding Sites in Promoters and Their In Silico DetectionThomas WernerAn Introduction to Multiple Sequence Alignment and AnalysisSteven M. Thompson3D Molecular Visualization with Protein ExplorerEric MartzMultiple Sequence Alignment and Analysis: The SeqLab Interface: A Practical GuideSteven M. ThompsonD. Analysis of Gene Expression: Microarrays and Other ToolsOverview of the Tools for Microarray Analysis: Transcription Profiling, DNA Chips, and Differential DisplayJeffrey A. KramerMicroarrays: Tools for Gene Expression AnalysisSorin DraghiciKnowledge Discovery from the Human TranscriptomeKousaku Okubo and Teruyoshi HishikiPart V. AppendicesAppendix 1: CD ContentsAppendix 2: A Collection of Useful Bioinformatic Tools and Molecular TablesAppendix 3: Simple UNIX CommandsIndex

Rezensionen

"...contains very valuable information on a wide range of topics related to bioinformatics research." - Heredity