Pentti Rautaharju, Farida Rautaharju

Investigative Electrocardiography in Epidemiological Studies and Clinical Trials (eBook, PDF)

• Format: PDF

Produktbeschreibung

Electrocardiology is a relatively new modality in clinical trials, but electrocardiograms (ECGs) have already become established as a valuable research tool for investigation of morbidity and mortality risk associated with various clinical and subclinical conditions. ECGs have also become a crucial tool when investigating adverse cardiac events associated with administration of new drugs.

Investigative Electrocardiography in Epidemiological Studies and Clinical Trials reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents.

With emphasis on providing international coverage of the topic, the well-respected authors present key information on ECG procedures, epidemiology, problem areas, mortality and morbidity risk. These topics are of particular interest to electrocardiologists, investigators in active ECG research in medical clinics participating in clinical trials, epidemiologists, cardiologists, pharmaceutical companies and regulatory bodies.

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Produktdetails

• Verlag: Springer London
• Seitenzahl: 289
• Erscheinungstermin: 12. März 2007
• Englisch
• ISBN-13: 9781846284816
• Artikelnr.: 37352315

Autorenporträt

The authors have closely collaborated for over a quarter of a Century in operating an academic ECG Center that has been in charge of ECG analysis of all major national health surveys conducted by the US National Center for Health Statistics, a series of large cardiovascular observational studies and clinical trials conducted by the US National Heart, Lung, and Blood Institute and several large clinical trials sponsored by pharmaceutical industry.

Inhaltsangabe

Investigative Electrocardiography in Epidemiological Studies and Clinical Trials.- Cardiac Excitation and Repolarization.- Electrocardiographic Lead Systems.- Normal and Arrhythmogenic Ionic Channel Mechanism.- Heart Rate and Heart Rate Variability.- Methodological Considerations in Heart Rate Variability Analysis.- Supraventricular Dysrhythmias.- Ectopic Ventricular Activity.- Record Length, Spontaneous Variability and Suppression of Ectopic Ventricular Complex Activity by Drugs.- Left Ventricular Hypertrophy.- Normal Standards for Cornell Voltage, Cornell Product and Sokolow-Lyon Voltage.- Prolonged Ventricular Excitation.- Old Myocardial Infarction.- Attributable Risk.- Primary Repolarization Abnormalities.- Procedures for Determination of the Spatial QRS/T Angle from Conventional ECG Measurements.- QT Prolongation and QT Dispersion - a Critical Evaluation.- Normal ECG Standards for Adults by Gender, Age, and Ethnicity.- ECG Intervals: Tables.- ECG Wave Amplitudes*: Tables.- ECG Vector Components and Spatial Magnitudes at Normalized Time Scale: Tables.- ECG Amplitudes at 10ms Intervals: Tables.- Repolarization Waveform Vectors: Tables.

Rezensionen

From the reviews:

"This book reviews common ECG abnormalities in various populations and focuses on the prevalence and incidence of these abnormalities as well as the prognostic implications of the findings. It uniquely provides an extensive series of tables listing normal standard of ECG intervals, amplitudes, and vectors in various populations ... . Investigators using electrocardiography as a research tool are the intended audience ... . This is a thorough book that will be useful to its targeted audience." (Marc N. Saad, Doody's Review Service, August, 2008)