Linking Environmental Exposure to Neurodevelopmental Disorders (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Advances in Neurotoxicology, Volume Two, addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson's disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike.

• Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology
• Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers
• Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America
• Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 312
• Erscheinungstermin: 24. Mai 2018
• Englisch
• ISBN-13: 9780128155523
• Artikelnr.: 54792770

Autorenporträt

Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control), and is a member of the Neurotoxicology and Alcohol study section (NIH). Research in our lab focuses on the following topics: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of MeHg uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg's neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of

cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. Our studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.

Inhaltsangabe

1. The Neurodevelopmental Toxicity of Lead: History, Epidemiology, and Public Health Implications
David C. Bellinger, Ashley Malin, Robert O. Wright
2. Neurodevelopmental Effects of Mercury
Cláudia S. Oliveira, Pablo A. Nogara, Daniel M.P. Ardisson-Araújo, Michael Aschner, João B.T. Rocha, José G. Dórea
3. Connections Between Manganese Neurotoxicity and Neurological Disease
Rachana Nitin, Aaron B. Bowman
4. Developmental Neurotoxicity of Alcohol: Effects and Mechanisms of Ethanol on the Developing Brain
Xiaolu Zhang, Joel G. Hashimoto, Marina Guizzetti
5. Possible Mechanisms of Developmental Neurotoxicity of Organophosphate Insecticides
Russell L. Carr, Navatha Alugubelly, Afzaal N. Mohammed
6. Chronic Nicotine Effects on Memory and Nicotine Self-Administration: Age of Exposure is Key
Edward D. Levin
7. Developmental Neurotoxicity of Endocrine Disruptor Chemicals: A Challenge for Behavioral Toxicology
Gemma Calamandrei, Laura Ricceri
8. Neurodevelopment: Inflammation Matters
Randall L. Davis
9. Enduring Behavioral and Brain Impacts of Prenatal Stress and Childhood Adversity and Their Potential Multigenerational Consequences
Deborah A. Cory-Slechta