Lipid Oxidation in Health and Disease (eBook, ePUB)

Redaktion: Spickett, Corinne M.; Forman, Henry Jay

• Format: ePub

Produktbeschreibung

Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. This book provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes. Topics include the mechanisms of lipid oxidation, antioxidant defenses, lipid oxidation products, cell signaling, and the roles of oxidized lipids in specific diseases. The book also discusses drug targeting and the therapeutic potential of oxidized lipids

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Produktdetails

• Verlag: Taylor & Francis
• Erscheinungstermin: 3. März 2015
• Englisch
• ISBN-13: 9781040194522
• Artikelnr.: 72536297

Autorenporträt

Corinne M. Spickett is a reader at Aston University in Birmingham, UK. She has studied the analysis of phospholipid oxidation by electrospray mass spectrometry and the biological effects of oxidized lipids. More recently, she expanded her research to include analysis of protein oxidation and formation of lipoxidation products during inflammation, and has been developing label-free, semi-targeted approaches to their identification in biological samples. Henry Jay Forman is a distinguished professor of biochemistry and chemistry and founding faculty at the University of California, Merced. His expertise is in the areas of oxidative stress and signal transduction. His major research achievements are pioneering work in mitochondrial superoxide production, redox signaling, and mechanisms of induced resistance to oxidative stress.

Inhaltsangabe

An Introduction to Redox Balance and Lipid Oxidation. CHEMISTRY AND
BIOCHEMISTRY OF LIPID OXIDATION. Nonenzymatic Mechanisms of Lipid
Oxidation. Enzymatic Oxidation of Polyunsaturated Fatty Acids. Halogenated
Lipids: Products of Peroxidase-Derived Reactive Halogenating Species
Targeting Conventional Lipids. Formation of Nitrated Lipids and Their
Biological Relevance. Protein Lipoxidation. Analysis of Lipid Peroxidation
Products in Health and Disease. SITES OF BIOLOGICAL ACTIONS OF OXIDIZED
LIPIDS. Oxidized Lipids as Damage-Associated Molecular Patterns in
Inflammatory Responses. Formation and Beneficial Roles of Polyunsaturated
Lipid Mediators: Lipoxins, Resolvins, Protectins, and Maresins. Pro- and
Anti-Inflammatory Action of Oxidized Phospholipids. Modulation of Toll-Like
Receptor Signaling by Oxidized Phospholipids. Dietary Oxidized Lipids as
Regulators of Intracellular Signaling Pathways: PPAR and NF-KB. Oxidized
and Nitrated Lipid Interactions with the. Keap1-Nrf2 Pathway. OXIDIZED
LIPIDS IN PATHOLOGY AND DISEASE. Role of Oxidized Phospholipids in
Cardiovascular Disease. Cholesterol Oxidation Products in the Initiation,
Progression, and Fate of Atherosclerotic Lesions. Lipid Peroxidation and
Age-Related Neurodegenerative. Disorders. Association of Oxidative Stress
and Lipids with Risk Factors of Metabolic Syndrome. Oxidized Lipid Products
and Carcinogenesis.