Liquid Chromatography Time-of-Flight Mass Spectrometry (eBook, PDF)

Principles, Tools, and Applications for Accurate Mass Analysis
Redaktion: Ferrer, Imma; Thurman, E. M.

• Format: PDF

Produktbeschreibung

Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants--such as antibiotics, steroids, analgesics--using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.

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Produktdetails

• Verlag: For Dummies
• Seitenzahl: 280
• Erscheinungstermin: 8. Mai 2009
• Englisch
• ISBN-13: 9780470429952
• Artikelnr.: 37292016

Autorenporträt

Imma Ferrer, PHD, has twelve years of hands-on experience in ion trap, triple quadrupole, and time-of-flight mass spectrometry of small molecules as applied to environmental and pharmaceutical chemistry. She is currently a Professional Research Associate of the Center for Environmental Mass Spectrometry at the University of Colorado in Boulder, Colorado. She is the author of the book Liquid Chromatography/Mass Spectrometry, MS/MS and Time-of-Flight MS: Analysis of Emerging Contaminants. She is also the author of numerous highly cited papers on the analysis of pesticides and pharmaceuticals by liquid chromatography mass spectrometry. E. Michael Thurman, PHD, is a highly cited scientist in environmental chemistry and an Emeritus Scientist with the U.S. Geological Survey. He is currently Director of the Center for Environmental Mass Spectrometry at the University of Colorado, in Boulder, Colorado. His bibliography consists of more than 200 publications in environmental chemistry, including more than 100 journal articles, twenty proceedings and chapters, and eighty U.S. Geological Survey publications. Dr. Thurman has published five books dedicated to the chemical analysis of pesticides and natural products, sample preparation, and mass spectrometry.

Inhaltsangabe

Part I: Principles and Theoretical Aspects of Accurate Mass.
Chapter 1: Accurate Mass Measurements with Orthogonal Axis Time of Flight
Mass Spectrometry (John C. Fjeldsted).
Chapter 2: The Mass Defect, Isotope Clusters, and Accurate Mass for
Elemental Determination (E. Michael Thurman and Imma Ferrer).
Part II: Tools for Unknown Identification using Accurate Mass.
Chapter 3: Ion Compostions Determined with Increasing Simplicity (Andrew H.
Grange and G. Wayne Sovocool).
Chapter 4: Use and Existence of Accurate Mass Databases and Elemental
Composition Tools for Target and Non-Target Analyses (Imma Ferrer and E.
Michael Thurman).
Chapter 5: Use of UPLC-(Q)-TOF-MS for Rapid Screening of Organic
Micropollutants in Water (Felix Hernandez, Juan V. Sancho and Maria
Ibanez).
Chapter 6: The Use of Accurate Mass, Isotope Ratios and MS/MS for the
Analysis of PPCPs in Water (Michael C. Zumwalt).
Part III: Applications of LC/TOF-MS for the identification of small
molecules.
Chapter 7: Applications of LC/TOF-MS in the Environmental Field: When Did
it Start and Where is it Going? (Imma Ferrer and E. Michael Thurman).
Chapter 8: Liquid Chromatography and Ambient Ionization Time-of-Flight Mass
Spectrometry for the Analysis of Genuine and Counterfeit Pharmaceuticals
(Facundo M. Fern ndez, Christina Y. Hampton, Leonard Nyadong, Arti Navare,
Mark Kwasnik).
Chapter 9: Quantitative Analysis of Veterinary Drug Residues by Sub 2 ?m
Particulate High-Performance Liquid Chromatography Columns and
Time-of-Flight Mass Spectrometry (UPLC-TOF)(Anton Kaufmann).
Chapter 10: Industrial Applications of Liquid Chromatography Time-of-Flight
Mass Spectrometry (Jeffrey R. Gilbert, Jesse L. Balcer, Scott A. Young, Dan
A. Markham, Dennis O. Duebelbeis, and Paul Lewer).
Chapter 11: Comprehensive Toxicological and Forensic Drug Screening by
LC/TOF-MS (Ilkka Ojanper", Anna Pelander and Suvi Ojanper).
12. Chapter 12: Application of UPLC/TOF-MS for Residue Analysis of
Veterinary Drugs and Growth Promoting Agents in Products of Animal Origin
(Alida(Linda) A.M. Stolker).
Chapter 13: Accurate Mass Measurements with a Reflectron Time-of-Flight
Mass Spectrometer and the Direct Analysis in Real Time (DART) Interface for
the Identification of Unknown Compounds Below Masses of 500 Da(O. David
Sparkman, Patrick R. Jones, Matthew Curtis).
Chapter 14: Comparison of LC/TOF-MS and LC/MS-MS for the Analysis of 100
Pesticides in Food: Finding the "Crossover Point" (E. Michael Thurman, Imma
Ferrer, Paul A. Zavitsanos and Jerry A. Zweigenbaum).