Long-lived Proteins in Human Aging and Disease (eBook, PDF)

Redaktion: Truscott, Roger J. W.

• Format: PDF

Produktbeschreibung

This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.

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Produktdetails

• Verlag: Wiley-VCH Verlag GmbH & Co. KGaA
• Erscheinungstermin: 12. Februar 2021
• Englisch
• ISBN-13: 9783527826735
• Artikelnr.: 61212739

Autorenporträt

Roger Truscott is a Research Professor at the Illawarra Health and Medical Research Institute, University of Wollongong. Having obtained his PhD at Melbourne University, he has spent most of his academic career working for the University of Sydney and the University of Wollongong. He has authored over 200 scientific publications. His main field of research is human aging with particular reference to age-related diseases, such as cataract. He has received numerous awards including a senior NHMRC fellowship and the National Foundation for Eye Research (USA) Cataract Research Award.

Inhaltsangabe

Modification of Long-lived Proteins and Protein InsolubilityChaperones as Agents that Detect and Bind to Modified Long-lived ProteinsAutophagy and ProteostasisComparison of PTMs of Long-lived Proteins from Various TissuesImaging Methodologies to Visualise Long-lived ProteinsGlycosylation and Other PTMs of Long-lived ProteinsHuman Aging and Long-lived Proteins