José Luis Millan

Mammalian Alkaline Phosphatases (eBook, PDF)

From Biology to Applications in Medicine and Biotechnology

• Format: PDF

Produktbeschreibung

A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: * The structure, regulation and expression of the AP genes * The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes * The phenotypic abnormalities of the different AP knockout mice * Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.

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Produktdetails

• Verlag: Wiley-VCH
• Seitenzahl: 322
• Erscheinungstermin: 13. Dezember 2006
• Englisch
• ISBN-13: 9783527607471
• Artikelnr.: 37356853

Autorenporträt

José Luis Millán received his early training in Clinical Chemistry at the University of Buenos Aires, Argentina and received pre-doctoral training at the La Jolla Cancer Research Foundation (the predecessor of the Burnham Institute) from 1977-1980. He completed his Ph.D. studies at the University of Umeå, Sweden in 1983. After a period of postdoctoral training at the La Jolla Cancer Research Foundation he was appointed to the staff in 1986. He was promoted to Associate Professor in 1989 and to Professor in 1994 at that Institution. He also held the Chair of Medical Genetics at the Department of Medical Biosciences, School of Medicine, Umeå University, Umeå, Sweden from 1995 to 2000. Dr. Millán is currently Professor at The Burnham Institute and he maintains adjunct affiliations with Umeå University and the Royal Academy of Medicine and Surgery, Murcia, Spain. Professor Millán has dedicated most of his scientific carrier to the understanding of the structure and biological functions of alkaline phosphatases during development and the significance of their re-expression in malignancy. This book highlights and discusses the major advances made in this field in the last 25 years.

Inhaltsangabe

PART I: GENE AND PROTEIN STRUCTURE1 Gene Structure2 Developmental Expression3 Gene Regulation4 Protein Structure and Functional Domains5 Enzymatic Properties6 Epitope MapsPART II: IN VIVO FUNCTIONS7 The In Vivo Role of TNAP8 Knockout Mouse ModelsPART III: AP EXPRESSION IN HEALTH AND DISEASE9 APs as Physiological and Disease Markers10 Neoplastic Expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP IsozymesPART IV: USES OF APS IN INDUSTRY AND BIOTECHNOLOGY11 Applications of Recombinant APs12 Use of APs in Prodrug Converting Strategies13 APs as Therapeutic Agents14 APs in the Food Industry15 Veterinary Uses of AP Determinations16 Methodologies