Philip A. Rea

Managing Discovery in the Life Sciences (eBook, ePUB)

Harnessing Creativity to Drive Biomedical Innovation

• Format: ePub

Produktbeschreibung

In this book, distinguished scholars Philip A. Rea, Mark V. Pauly, and Lawton R. Burns explore the science and management behind marketable biomedical innovations. They look at how the science actually played out through the interplay of personalities, the cultures within and between academic and corporate entities, and the significance of serendipity not as a mysterious phenomenon but one intrinsic to the successes and failures of the experimental approach. With newly aggregated data and case studies, they consider the fundamental economic underpinnings of investor-driven discovery management, not as an obstacle or deficiency as its critics would contend or as something beyond reproach as some of its proponents might claim, but as the only means by which scientists and managers can navigate the unknowable to discover new products and decide how to sell them so as to maximize the likelihood of establishing a sustainable pipeline for still more marketable biomedical innovations.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 1. Februar 2018
• Englisch
• ISBN-13: 9781108675543
• Artikelnr.: 50926087

Autorenporträt

Philip A. Rea, Professor of Biology and Rebecka and Arie Belldegrun Distinguished Director, co-founded the Roy and Diana Vagelos Program in Life Sciences and Management at the University of Pennsylvania. A Fellow of the American Association for the Advancement of Science, he has received several prestigious prizes and awards for his pioneering research on membrane transporters and his creative science teaching, including the President's Medal of the Society for Experimental Biology and a Lindback Foundation Award for Distinguished Teaching.

Inhaltsangabe

Preface; 1. Discoveries now and then: shifting incentives and expectations
Mark V. Pauly, Philip A. Rea and Lawton R. Burns; 2. Pharma trends: not
what they seem Kyle Myers and Mark V. Pauly; 3. Profit maximizing drug
firms: models and myths Vicki Chen and Mark V. Pauly; Transitional note:
introduction to the case studies; 4. The Statins: cholesterols
'penicillins' Philip A. Rea; 5. ACE inhibitors: kidney clamps, snake venoms
and peptidomimetics Alec Ren and Philip A. Rea; 6. Angioplasty: catheters,
guidewires and balloons Simon Basseyn, Sourav Bose, Lawton R. Burns and
Chris Groskaufmanis; 7. Hepatitis C: when cures and prices go viral Stephen
Goldstein, Peter M. Stokes, Connie Lu and Philip A. Rea; 8. Alzheimer's:
America's new most feared disease Julian Pei, John Q. Trojanowski, Peter M.
Stokes, Katherine Clark, Mark V. Pauly and Philip A. Rea; 9. Metformin: to
the brink and back Anderson Y. Tien and Philip A Rea; 10. Medical genomics:
personalized precision Marc S. Williams; 11. Gleevec: from broken
chromosomes to precision cancer therapy Vivek Nimgaonkar and Philip A. Rea;
12. Regeneron: agility, resilience and balance Lawton R. Burns, Alex Rosen,
Steven Nichtberger and Philip A. Rea; 13. Avastin and Lucentis: both for
eyesight in hindsight Osama Ahmed, Mark V. Pauly, Peter M. Stokes and
Philip A. Rea; 14. CAR T-cell therapy: cures for ALL and more? Stephen
Goldstein, Amy Le and Philip A. Rea; 15. Organizing discovery: wild ducks
nested in multilevel ecosystems Lawton R. Burns and Philip A. Rea; 16. Can
government help with the creatively unexpected? Mark V. Pauly, Lawton R.
Burns and Philip A. Rea; Appendix: three key elements in the discovery
process: historical and philosophical antecedents Mark V. Pauly; Index.