Manual of Biological Markers of Disease (eBook, PDF)

Redaktion: Venrooij, W. J. Van; Maini, Ravinder N.

• Format: PDF

Produktbeschreibung

A comprehensive reference work: This looseleaf work is an authoritative compilation of methods for the detection of autoantibodies (Section A: Methods of Autoantibody Detection); the structure, function, and molecular and biochemical concepts of autoantigens (Section B: Autoantigens); and the clinical significance of measuring autoantibodies in patients with rheumatic, connective tissue and autoimmune diseases (Section C: Clinical Significance of Autoantibodies). This unique work brings together all the molecular and medical information - very difficult to retrieve otherwise - in ONE publication. The Editors and contributors are leading experts in the immunological, molecular biological, and clinical fields. The format of this looseleaf publication allows regular updating of data as well as inclusion of new advances in research on autoimmunity. Until now, the work (Basic work including Supplement 1) included Section A, and the larger part of Section B, both in an attractive and robust ringbinder. Audience: By nature and design of this exciting reference work, it is especially aimed at scientists, including immunologists, pathologists and molecular biologists, and clinical chemists, as well as clinicians specializing in rheumatic diseases and autoimmune disorders, inflammation or clinical immunology. Supplement 2: This supplement primarily contains Section C (Clinical Significance of Autoantibodies). As in the other sections, the contents are presented in a consistently structured manner, beautifully illustrated with photos and schematic figures. Extensive literature references are provided. Also, this supplement includes an addition to Section B (Autoantigens), being chapter B.1.5: The Antigens Defined by Antikeratin Antibodies (AKA).

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 742
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9789401116701
• Artikelnr.: 44183070

Inhaltsangabe

Section A: Methods of Autoantibody Detection, Introduction The Editors.- 1. International cooperative activities in standardization of antinuclear antibodies.- 2. Detection of antinuclear antibodies by immunofluorescence.- 3. Counterimmunoelectrophoresis and immunodiffusion for the detection of antibodies to soluble cellular antigens.- 4. Protein Blotting.- 5. Enzyme-linked immunosorbant assay in the rheumatological laboratory.- 6. Immunoprecipitation of labelled proteins.- 7. Analysis of autoimmune sera by immunoprecipitation of cellular RNPs.- 8. Measurement of antibodies to DNA.- 9. Methods to detect autoantibodies to neutrophilic granulocyte.- 10. Detection of antiperinuclear factor and antikeratin antibodies.- 11. Standards and reference preparations.- Section B: Autoantigens, Introduction The Editors.- 1. Autoantigens in Rheumatoid Arthritis (RA).- 1. RF (rheumatoïd factor).- 2. APF (antiperinuclear factor).- 3. RA-33 (hnRNP-A2).- 4. Collagen II.- 5. The autoantigens defined by antikeratin antibodies (AKA).- 2. Autoantigens in Systemic Lupus Erythematosus (SLE).- 1. DNA.- 2. Histones.- 3. Ubiquitin.- 4. Sm.- 5. Ribosomal RNP.- 6. Ku.- 7. PCNA.- 8. Phospholipids.- 3. Autoantigens in SLE-overlap syndromes.- 1. The U1 snRNP complex.- 4. Autoantigens in Sjögren's syndrome.- 1. Ro/SS-A.- 2. La/SS-B.- 5. Autoantigens in Scleroderma.- 1. DNA Topoisomerase 1.- 2. Centromere Proteins.- 3. Fibrillarin.- 4. PM/Scl.- 6. Autoantigens in Myositis.- 1. Transfer RNA synthetases.- 7. Autoantigens in Vasculitis.- 1. Proteinase 3 (c-ANCA).- 2. Myeloperoxidase (MPO).- 8. Autoantigens in other diseases.- 1. Mitochondrial autoantigens.- 2. P80 coilin.- Section C: Clinical Significance of Autoantibodies, Introduction The Editors.- 1. Autoantibodies in Rheumatoid Arthritis.- 1.1Rheumatoïd factor.- 2. Autoantibodies in SLE.- 2.1 Autoantibodies to double-stranded DNA.- 2.2 Autoantibodies to histones, Sm and ubiquitins.- 2.3 Autoantibodies to Ku and related antigens.- 2.4 Autoantibodies to PCNA.- 2.5 Autoantibodies to phospholipids.- 3. Autoantibodies in SLE-overlap syndromes.- 3.1 Autoantibodies to U1snRNP.- 4. Autoantibodies in Sjögren's syndrome.- Anti-Ro/SSA and anti-La/SSB antibodies.- 5. Autoantibodies in Scleroderma.- 5.1 Anti-centromere antibodies.- 6. Autoantibodies in Myositis.- 6.1 Transfer RNA synthetases.- 7. Autoantibodies in Vasculitis.- 7.1 Anti-neutrophil cytoplasmic antibody.- 8. Autoantibodies in other diseases.- 8.1 Anti-mitochondria] antibody in primary biliary cirrhosis.- 8.2 Autoantibodies to the coiled body and other nuclear bodies.