Mass Spectrometry Handbook (eBook, PDF)
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Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling…mehr
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Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.
Produktdetails
- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 1368
- Erscheinungstermin: 13. April 2012
- Englisch
- ISBN-13: 9781118180709
- Artikelnr.: 38233300
- Verlag: John Wiley & Sons
- Seitenzahl: 1368
- Erscheinungstermin: 13. April 2012
- Englisch
- ISBN-13: 9781118180709
- Artikelnr.: 38233300
Mike S. Lee is President of Milestone Development Services where he consults and develops workshops and symposia to support industry with innovative technologies and solutions. His research interests include the application of mass spectrometry for the analysis of proteins, natural products, drug metabolites, impurities, and degradants. Recently, he has been involved in the development of automated orthogonal control systems for electrospray ionization and the development of digital separation devices for sampling, separation, and enrichment.
FOREWORD xi PREFACE xiii CONTRIBUTORS xvii SECTION I BIOTECHNOLOGY/PROTEINS 1 1 Targeted Proteomics Using Immunoaffi nity Purifi cation 3 Karen R. Jonscher
Lei Jin
John C. Cambier
Shaikh M. Rahman
and Jacob E. Friedman 2 Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifi cations by Lipid Peroxidation Products 23 Navin Rauniyar and Laszlo Prokai 3 Imaging Mass Spectrometry (IMS) for Biological Application 41 Yuki Sugiura
Ikuko Yao
and Mitsutoshi Setou 4 Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs 85 George W. Jackson
Rafal Drabek
Mithil Soni
Roger McNichols
Richard C. Willson
and George E. Fox SECTION II PHARMACEUTICAL 107 5 Preclinical Pharmacokinetics: Industrial Perspective 109 Ayman El-Kattan and Manthena Varma 6 LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective 119 Wenying Jian
Wilson Shou
Richard W. Edom
Naidong Weng
and Mingshe Zhu 7 Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies 171 Xiaoying Xu
Wenkui Li
and Francis L.S. Tse 8 Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS 191 Margrét Thorsteinsdóttir
Baldur Bragi Sigur?sson
and Gísli Bragason 9 Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS 209 Kevin A. Schug 10 Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture
Dynamics
and Interactions of Biopharmaceutical Products 227 Igor A. Kaltashov
Cedric E. Bobst
and Rinat R. Abzalimov 11 TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods 243 Satoka Aoyagi 12 Accelerator Mass Spectrometry in Pharmaceutical Development 259 Benjamin J. Stewart
Graham Bench
Bruce A. Buchholz
Kurt W. Haack
Michael A. Malfatti
Ted J. Ognibene
and Kenneth W. Turteltaub SECTION III CLINICAL ANALYSIS 271 13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism 273 Donald H. Chace 14 Mass Spectrometry for Steroid Analysis 297 William J. Griffi ths
Michael Ogundare
Anna Meljon
and Yuqin Wang SECTION IV FORENSICS 339 15 Forensic Applications of Isotope Ratio Mass Spectrometry 341 Sarah J. Benson 16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry 373 Michael E. Sigman and C. Douglas Clark SECTION V SPACE EXPLORATION 389 17 Mass Spectrometry in Solar System Exploration 391 Paul V. Johnson
Luther W. Beegle
and Isik Kanik 18 Application of GC × GC-TOFMS to the Characterization of Extraterrestrial Organic Matter 407 Jonathan S. Watson SECTION VI HOMELAND SECURITY 417 19 Methods of Mass Spectrometry in Homeland Security Applications 419 Ünige A. Laskay
Erin J. Kaleta
and Vicki H. Wysocki 20 Homeland Security 441 Christina L. Crawford and Herbert H. Hill
Jr. 21 Mass Spectrometry in Homeland Security 477 Yasuaki Takada 22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer 491 Gary S. Groenewold
Anthony D. Appelhans
Garold L. Gresham
and John E. Olson 23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios 509 R. Steven Pappas SECTION VII FOOD ANALYSIS 529 24 Mass Spectrometry in Agriculture
Food
and Flavors: Selected Applications 531 Maciej Stobiecki
Piotr Kachlicki
and Henryk Jeleñ 25 Top-Down Proteomic Identifi cation of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS 559 Clifton K. Fagerquist and Omar Sultan SECTION VIII ENVIRONMENTAL 575 26 Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry 577 Wolfgang Schwack 27 Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry 593 Chongzheng Na and Terese M. Olson 28 Proton Transfer Reaction Mass Spectrometry (PTR-MS) 605 Yujie Wang
Chengyin Shen
Jianquan Li
Haihe Jiang
and Yannan Chu 29 Determination of Chlorinated Compounds in Dialysis Water and in Biological Fluids/Matrices 631 Diana Poli SECTION IX GEOLOGICAL 645 30 Mass Spectrometry Techniques for Analysis of Oil and Gas Trapped in Fluid Inclusions 647 Simon C. George
Herbert Volk
and Adriana Dutkiewicz 31 LA-MC-ICP-MS Applied to U-Pb Zircon Geochronology 675 Alain Cocherie and Michèle Robert 32 Hydrocarbon Processing 707 Maoqi Feng
Thomas Andrews
and Eloy Flores III 33 Hydrocarbon Processing: MALDI-MS of Polydisperse Hydrocarbon Samples 725 Alan A. Herod 34 Renewable Energy: Mass Spectrometry in Biofuel Research 749 Ingvar Eide and Kolbjørn Zahlsen SECTION X ARCHAEOLOGY 763 35 Mass Spectrometry in Archaeology 765 Robert Hedges and James McCullagh 36 Archaeometric Data from Mass Spectrometric Analysis of Organic Materials: Proteins
Lipids
Terpenoid Resins
Lignocellulosic Polymers
and Dyestuff 797 Maria Perla Colombini
Francesca Modugno
and Erika Ribechini 37 Laser Ablation ICP-MS in Archaeology 829 Hector Neff 38 Spatially Resolved MS in the Study of Art and Archaeological Objects 845 Giuseppe Spoto 39 Laser Ablation-Inductively Coupled Plasma Mass Spectrometry for the Investigation of Archaeological Samples 859 Martín Resano
Esperanza García-Ruiz
and Frank Vanhaecke SECTION XI SURFACE ANALYSIS 885 40 Mass Spectrometry in Semiconductor Research 887 Stefan Flege and Wolfgang Ensinger 41 Analysis of Thin and Thick Films 943 Philippe Le Coustumer
Patrick Chapon
Agnès Tempez
Yuriy Popov
George Thompson
Igor Molchan
Nicolas Trigoulet
Peter Skeldon
Antonino Licciardello
Nunzio Tuccitto
Ivan Delfanti
Katrin Fuhrer
Marc Gonin
James Whitby
Markus Hohl
Christian Tanner
Nerea Bordel Garcia
Lara Lobo Revilla
Jorge Pisonero
Rosario Pereiro
Cristina Gonzalez Gago
Alfredo Sanz Medel
Mihai Ganciu Petcu
Ani Surmeian
Constantin Diplasu
Andreea Groza
Norbert Jakubowski
Roland Dorka
Stela Canulescu
Johann Michler
Philippe Belenguer
Thomas Nelis
Abdellatif Zahri
Philippe Guillot
Laurent Thérèse
Arnaud Littner
Richard Vaux
Julien Malherbe
Frédéric Huneau
Fred Stevie
and Hugues François-Saint-Cyr 42 SIMS for Organic Film Analysis 961 Taoufi q Mouhib and Arnaud Delcorte 43 Ceramics: Contribution of Secondary Ion Mass Spectrometry (SIMS) to the Study of Crystal Chemistry of Mica Minerals 1017 Luisa Ottolini
Emanuela Schingaro
and Fernando Scordari SECTION XII POLYMERS 1061 44 ETV-ICPMS for Analysis of Polymers 1063 Maite Aramendía Marzo
Martín Resano
and Frank Vanhaecke 45 Polymers 1079 Maurizio S. Montaudo and Salvatore Battiato 46 Mass Spectroscopy in Polymer Research 1107 Jale Hacaloglu and Talat Yalcin 47 Laser Mass Spectrometry Applied to the Analysis of Polymers 1135 Jérôme Bour and David Ruch SECTION XIII ANALYTICAL TECHNIQUES 1143 48 Measuring Thermodynamic Properties of Metals and Alloys 1145 Evan H. Copland and Nathan S. Jacobson 49 High-Performance Thin-Layer Chromatography-Mass Spectrometry for Analysis of Small Molecules 1181 Gertrud E. Morlock 50 Laser Ionization Mass Spectrometry of Inorganic Ions 1207 Julius Pavlov and Athula B. Attygalle 51 Mass Spectrometry in the SSITKA Studies 1229 L.G. Pinaeva
E.M. Sadovskaya
A.P. Suknev
V.B. Goncharov
and B.S. Bal'zhinimaev 52 Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences 1257 Elena Crespo
Marco M.L. Steeghs
Simona M. Cristescu
and Frans J.M. Harren INDEX 1283
Lei Jin
John C. Cambier
Shaikh M. Rahman
and Jacob E. Friedman 2 Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifi cations by Lipid Peroxidation Products 23 Navin Rauniyar and Laszlo Prokai 3 Imaging Mass Spectrometry (IMS) for Biological Application 41 Yuki Sugiura
Ikuko Yao
and Mitsutoshi Setou 4 Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs 85 George W. Jackson
Rafal Drabek
Mithil Soni
Roger McNichols
Richard C. Willson
and George E. Fox SECTION II PHARMACEUTICAL 107 5 Preclinical Pharmacokinetics: Industrial Perspective 109 Ayman El-Kattan and Manthena Varma 6 LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective 119 Wenying Jian
Wilson Shou
Richard W. Edom
Naidong Weng
and Mingshe Zhu 7 Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies 171 Xiaoying Xu
Wenkui Li
and Francis L.S. Tse 8 Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS 191 Margrét Thorsteinsdóttir
Baldur Bragi Sigur?sson
and Gísli Bragason 9 Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS 209 Kevin A. Schug 10 Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture
Dynamics
and Interactions of Biopharmaceutical Products 227 Igor A. Kaltashov
Cedric E. Bobst
and Rinat R. Abzalimov 11 TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods 243 Satoka Aoyagi 12 Accelerator Mass Spectrometry in Pharmaceutical Development 259 Benjamin J. Stewart
Graham Bench
Bruce A. Buchholz
Kurt W. Haack
Michael A. Malfatti
Ted J. Ognibene
and Kenneth W. Turteltaub SECTION III CLINICAL ANALYSIS 271 13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism 273 Donald H. Chace 14 Mass Spectrometry for Steroid Analysis 297 William J. Griffi ths
Michael Ogundare
Anna Meljon
and Yuqin Wang SECTION IV FORENSICS 339 15 Forensic Applications of Isotope Ratio Mass Spectrometry 341 Sarah J. Benson 16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry 373 Michael E. Sigman and C. Douglas Clark SECTION V SPACE EXPLORATION 389 17 Mass Spectrometry in Solar System Exploration 391 Paul V. Johnson
Luther W. Beegle
and Isik Kanik 18 Application of GC × GC-TOFMS to the Characterization of Extraterrestrial Organic Matter 407 Jonathan S. Watson SECTION VI HOMELAND SECURITY 417 19 Methods of Mass Spectrometry in Homeland Security Applications 419 Ünige A. Laskay
Erin J. Kaleta
and Vicki H. Wysocki 20 Homeland Security 441 Christina L. Crawford and Herbert H. Hill
Jr. 21 Mass Spectrometry in Homeland Security 477 Yasuaki Takada 22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer 491 Gary S. Groenewold
Anthony D. Appelhans
Garold L. Gresham
and John E. Olson 23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios 509 R. Steven Pappas SECTION VII FOOD ANALYSIS 529 24 Mass Spectrometry in Agriculture
Food
and Flavors: Selected Applications 531 Maciej Stobiecki
Piotr Kachlicki
and Henryk Jeleñ 25 Top-Down Proteomic Identifi cation of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS 559 Clifton K. Fagerquist and Omar Sultan SECTION VIII ENVIRONMENTAL 575 26 Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry 577 Wolfgang Schwack 27 Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry 593 Chongzheng Na and Terese M. Olson 28 Proton Transfer Reaction Mass Spectrometry (PTR-MS) 605 Yujie Wang
Chengyin Shen
Jianquan Li
Haihe Jiang
and Yannan Chu 29 Determination of Chlorinated Compounds in Dialysis Water and in Biological Fluids/Matrices 631 Diana Poli SECTION IX GEOLOGICAL 645 30 Mass Spectrometry Techniques for Analysis of Oil and Gas Trapped in Fluid Inclusions 647 Simon C. George
Herbert Volk
and Adriana Dutkiewicz 31 LA-MC-ICP-MS Applied to U-Pb Zircon Geochronology 675 Alain Cocherie and Michèle Robert 32 Hydrocarbon Processing 707 Maoqi Feng
Thomas Andrews
and Eloy Flores III 33 Hydrocarbon Processing: MALDI-MS of Polydisperse Hydrocarbon Samples 725 Alan A. Herod 34 Renewable Energy: Mass Spectrometry in Biofuel Research 749 Ingvar Eide and Kolbjørn Zahlsen SECTION X ARCHAEOLOGY 763 35 Mass Spectrometry in Archaeology 765 Robert Hedges and James McCullagh 36 Archaeometric Data from Mass Spectrometric Analysis of Organic Materials: Proteins
Lipids
Terpenoid Resins
Lignocellulosic Polymers
and Dyestuff 797 Maria Perla Colombini
Francesca Modugno
and Erika Ribechini 37 Laser Ablation ICP-MS in Archaeology 829 Hector Neff 38 Spatially Resolved MS in the Study of Art and Archaeological Objects 845 Giuseppe Spoto 39 Laser Ablation-Inductively Coupled Plasma Mass Spectrometry for the Investigation of Archaeological Samples 859 Martín Resano
Esperanza García-Ruiz
and Frank Vanhaecke SECTION XI SURFACE ANALYSIS 885 40 Mass Spectrometry in Semiconductor Research 887 Stefan Flege and Wolfgang Ensinger 41 Analysis of Thin and Thick Films 943 Philippe Le Coustumer
Patrick Chapon
Agnès Tempez
Yuriy Popov
George Thompson
Igor Molchan
Nicolas Trigoulet
Peter Skeldon
Antonino Licciardello
Nunzio Tuccitto
Ivan Delfanti
Katrin Fuhrer
Marc Gonin
James Whitby
Markus Hohl
Christian Tanner
Nerea Bordel Garcia
Lara Lobo Revilla
Jorge Pisonero
Rosario Pereiro
Cristina Gonzalez Gago
Alfredo Sanz Medel
Mihai Ganciu Petcu
Ani Surmeian
Constantin Diplasu
Andreea Groza
Norbert Jakubowski
Roland Dorka
Stela Canulescu
Johann Michler
Philippe Belenguer
Thomas Nelis
Abdellatif Zahri
Philippe Guillot
Laurent Thérèse
Arnaud Littner
Richard Vaux
Julien Malherbe
Frédéric Huneau
Fred Stevie
and Hugues François-Saint-Cyr 42 SIMS for Organic Film Analysis 961 Taoufi q Mouhib and Arnaud Delcorte 43 Ceramics: Contribution of Secondary Ion Mass Spectrometry (SIMS) to the Study of Crystal Chemistry of Mica Minerals 1017 Luisa Ottolini
Emanuela Schingaro
and Fernando Scordari SECTION XII POLYMERS 1061 44 ETV-ICPMS for Analysis of Polymers 1063 Maite Aramendía Marzo
Martín Resano
and Frank Vanhaecke 45 Polymers 1079 Maurizio S. Montaudo and Salvatore Battiato 46 Mass Spectroscopy in Polymer Research 1107 Jale Hacaloglu and Talat Yalcin 47 Laser Mass Spectrometry Applied to the Analysis of Polymers 1135 Jérôme Bour and David Ruch SECTION XIII ANALYTICAL TECHNIQUES 1143 48 Measuring Thermodynamic Properties of Metals and Alloys 1145 Evan H. Copland and Nathan S. Jacobson 49 High-Performance Thin-Layer Chromatography-Mass Spectrometry for Analysis of Small Molecules 1181 Gertrud E. Morlock 50 Laser Ionization Mass Spectrometry of Inorganic Ions 1207 Julius Pavlov and Athula B. Attygalle 51 Mass Spectrometry in the SSITKA Studies 1229 L.G. Pinaeva
E.M. Sadovskaya
A.P. Suknev
V.B. Goncharov
and B.S. Bal'zhinimaev 52 Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences 1257 Elena Crespo
Marco M.L. Steeghs
Simona M. Cristescu
and Frans J.M. Harren INDEX 1283
FOREWORD xi PREFACE xiii CONTRIBUTORS xvii SECTION I BIOTECHNOLOGY/PROTEINS 1 1 Targeted Proteomics Using Immunoaffi nity Purifi cation 3 Karen R. Jonscher
Lei Jin
John C. Cambier
Shaikh M. Rahman
and Jacob E. Friedman 2 Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifi cations by Lipid Peroxidation Products 23 Navin Rauniyar and Laszlo Prokai 3 Imaging Mass Spectrometry (IMS) for Biological Application 41 Yuki Sugiura
Ikuko Yao
and Mitsutoshi Setou 4 Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs 85 George W. Jackson
Rafal Drabek
Mithil Soni
Roger McNichols
Richard C. Willson
and George E. Fox SECTION II PHARMACEUTICAL 107 5 Preclinical Pharmacokinetics: Industrial Perspective 109 Ayman El-Kattan and Manthena Varma 6 LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective 119 Wenying Jian
Wilson Shou
Richard W. Edom
Naidong Weng
and Mingshe Zhu 7 Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies 171 Xiaoying Xu
Wenkui Li
and Francis L.S. Tse 8 Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS 191 Margrét Thorsteinsdóttir
Baldur Bragi Sigur?sson
and Gísli Bragason 9 Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS 209 Kevin A. Schug 10 Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture
Dynamics
and Interactions of Biopharmaceutical Products 227 Igor A. Kaltashov
Cedric E. Bobst
and Rinat R. Abzalimov 11 TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods 243 Satoka Aoyagi 12 Accelerator Mass Spectrometry in Pharmaceutical Development 259 Benjamin J. Stewart
Graham Bench
Bruce A. Buchholz
Kurt W. Haack
Michael A. Malfatti
Ted J. Ognibene
and Kenneth W. Turteltaub SECTION III CLINICAL ANALYSIS 271 13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism 273 Donald H. Chace 14 Mass Spectrometry for Steroid Analysis 297 William J. Griffi ths
Michael Ogundare
Anna Meljon
and Yuqin Wang SECTION IV FORENSICS 339 15 Forensic Applications of Isotope Ratio Mass Spectrometry 341 Sarah J. Benson 16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry 373 Michael E. Sigman and C. Douglas Clark SECTION V SPACE EXPLORATION 389 17 Mass Spectrometry in Solar System Exploration 391 Paul V. Johnson
Luther W. Beegle
and Isik Kanik 18 Application of GC × GC-TOFMS to the Characterization of Extraterrestrial Organic Matter 407 Jonathan S. Watson SECTION VI HOMELAND SECURITY 417 19 Methods of Mass Spectrometry in Homeland Security Applications 419 Ünige A. Laskay
Erin J. Kaleta
and Vicki H. Wysocki 20 Homeland Security 441 Christina L. Crawford and Herbert H. Hill
Jr. 21 Mass Spectrometry in Homeland Security 477 Yasuaki Takada 22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer 491 Gary S. Groenewold
Anthony D. Appelhans
Garold L. Gresham
and John E. Olson 23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios 509 R. Steven Pappas SECTION VII FOOD ANALYSIS 529 24 Mass Spectrometry in Agriculture
Food
and Flavors: Selected Applications 531 Maciej Stobiecki
Piotr Kachlicki
and Henryk Jeleñ 25 Top-Down Proteomic Identifi cation of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS 559 Clifton K. Fagerquist and Omar Sultan SECTION VIII ENVIRONMENTAL 575 26 Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry 577 Wolfgang Schwack 27 Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry 593 Chongzheng Na and Terese M. Olson 28 Proton Transfer Reaction Mass Spectrometry (PTR-MS) 605 Yujie Wang
Chengyin Shen
Jianquan Li
Haihe Jiang
and Yannan Chu 29 Determination of Chlorinated Compounds in Dialysis Water and in Biological Fluids/Matrices 631 Diana Poli SECTION IX GEOLOGICAL 645 30 Mass Spectrometry Techniques for Analysis of Oil and Gas Trapped in Fluid Inclusions 647 Simon C. George
Herbert Volk
and Adriana Dutkiewicz 31 LA-MC-ICP-MS Applied to U-Pb Zircon Geochronology 675 Alain Cocherie and Michèle Robert 32 Hydrocarbon Processing 707 Maoqi Feng
Thomas Andrews
and Eloy Flores III 33 Hydrocarbon Processing: MALDI-MS of Polydisperse Hydrocarbon Samples 725 Alan A. Herod 34 Renewable Energy: Mass Spectrometry in Biofuel Research 749 Ingvar Eide and Kolbjørn Zahlsen SECTION X ARCHAEOLOGY 763 35 Mass Spectrometry in Archaeology 765 Robert Hedges and James McCullagh 36 Archaeometric Data from Mass Spectrometric Analysis of Organic Materials: Proteins
Lipids
Terpenoid Resins
Lignocellulosic Polymers
and Dyestuff 797 Maria Perla Colombini
Francesca Modugno
and Erika Ribechini 37 Laser Ablation ICP-MS in Archaeology 829 Hector Neff 38 Spatially Resolved MS in the Study of Art and Archaeological Objects 845 Giuseppe Spoto 39 Laser Ablation-Inductively Coupled Plasma Mass Spectrometry for the Investigation of Archaeological Samples 859 Martín Resano
Esperanza García-Ruiz
and Frank Vanhaecke SECTION XI SURFACE ANALYSIS 885 40 Mass Spectrometry in Semiconductor Research 887 Stefan Flege and Wolfgang Ensinger 41 Analysis of Thin and Thick Films 943 Philippe Le Coustumer
Patrick Chapon
Agnès Tempez
Yuriy Popov
George Thompson
Igor Molchan
Nicolas Trigoulet
Peter Skeldon
Antonino Licciardello
Nunzio Tuccitto
Ivan Delfanti
Katrin Fuhrer
Marc Gonin
James Whitby
Markus Hohl
Christian Tanner
Nerea Bordel Garcia
Lara Lobo Revilla
Jorge Pisonero
Rosario Pereiro
Cristina Gonzalez Gago
Alfredo Sanz Medel
Mihai Ganciu Petcu
Ani Surmeian
Constantin Diplasu
Andreea Groza
Norbert Jakubowski
Roland Dorka
Stela Canulescu
Johann Michler
Philippe Belenguer
Thomas Nelis
Abdellatif Zahri
Philippe Guillot
Laurent Thérèse
Arnaud Littner
Richard Vaux
Julien Malherbe
Frédéric Huneau
Fred Stevie
and Hugues François-Saint-Cyr 42 SIMS for Organic Film Analysis 961 Taoufi q Mouhib and Arnaud Delcorte 43 Ceramics: Contribution of Secondary Ion Mass Spectrometry (SIMS) to the Study of Crystal Chemistry of Mica Minerals 1017 Luisa Ottolini
Emanuela Schingaro
and Fernando Scordari SECTION XII POLYMERS 1061 44 ETV-ICPMS for Analysis of Polymers 1063 Maite Aramendía Marzo
Martín Resano
and Frank Vanhaecke 45 Polymers 1079 Maurizio S. Montaudo and Salvatore Battiato 46 Mass Spectroscopy in Polymer Research 1107 Jale Hacaloglu and Talat Yalcin 47 Laser Mass Spectrometry Applied to the Analysis of Polymers 1135 Jérôme Bour and David Ruch SECTION XIII ANALYTICAL TECHNIQUES 1143 48 Measuring Thermodynamic Properties of Metals and Alloys 1145 Evan H. Copland and Nathan S. Jacobson 49 High-Performance Thin-Layer Chromatography-Mass Spectrometry for Analysis of Small Molecules 1181 Gertrud E. Morlock 50 Laser Ionization Mass Spectrometry of Inorganic Ions 1207 Julius Pavlov and Athula B. Attygalle 51 Mass Spectrometry in the SSITKA Studies 1229 L.G. Pinaeva
E.M. Sadovskaya
A.P. Suknev
V.B. Goncharov
and B.S. Bal'zhinimaev 52 Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences 1257 Elena Crespo
Marco M.L. Steeghs
Simona M. Cristescu
and Frans J.M. Harren INDEX 1283
Lei Jin
John C. Cambier
Shaikh M. Rahman
and Jacob E. Friedman 2 Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifi cations by Lipid Peroxidation Products 23 Navin Rauniyar and Laszlo Prokai 3 Imaging Mass Spectrometry (IMS) for Biological Application 41 Yuki Sugiura
Ikuko Yao
and Mitsutoshi Setou 4 Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs 85 George W. Jackson
Rafal Drabek
Mithil Soni
Roger McNichols
Richard C. Willson
and George E. Fox SECTION II PHARMACEUTICAL 107 5 Preclinical Pharmacokinetics: Industrial Perspective 109 Ayman El-Kattan and Manthena Varma 6 LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective 119 Wenying Jian
Wilson Shou
Richard W. Edom
Naidong Weng
and Mingshe Zhu 7 Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies 171 Xiaoying Xu
Wenkui Li
and Francis L.S. Tse 8 Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS 191 Margrét Thorsteinsdóttir
Baldur Bragi Sigur?sson
and Gísli Bragason 9 Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS 209 Kevin A. Schug 10 Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture
Dynamics
and Interactions of Biopharmaceutical Products 227 Igor A. Kaltashov
Cedric E. Bobst
and Rinat R. Abzalimov 11 TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods 243 Satoka Aoyagi 12 Accelerator Mass Spectrometry in Pharmaceutical Development 259 Benjamin J. Stewart
Graham Bench
Bruce A. Buchholz
Kurt W. Haack
Michael A. Malfatti
Ted J. Ognibene
and Kenneth W. Turteltaub SECTION III CLINICAL ANALYSIS 271 13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism 273 Donald H. Chace 14 Mass Spectrometry for Steroid Analysis 297 William J. Griffi ths
Michael Ogundare
Anna Meljon
and Yuqin Wang SECTION IV FORENSICS 339 15 Forensic Applications of Isotope Ratio Mass Spectrometry 341 Sarah J. Benson 16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry 373 Michael E. Sigman and C. Douglas Clark SECTION V SPACE EXPLORATION 389 17 Mass Spectrometry in Solar System Exploration 391 Paul V. Johnson
Luther W. Beegle
and Isik Kanik 18 Application of GC × GC-TOFMS to the Characterization of Extraterrestrial Organic Matter 407 Jonathan S. Watson SECTION VI HOMELAND SECURITY 417 19 Methods of Mass Spectrometry in Homeland Security Applications 419 Ünige A. Laskay
Erin J. Kaleta
and Vicki H. Wysocki 20 Homeland Security 441 Christina L. Crawford and Herbert H. Hill
Jr. 21 Mass Spectrometry in Homeland Security 477 Yasuaki Takada 22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer 491 Gary S. Groenewold
Anthony D. Appelhans
Garold L. Gresham
and John E. Olson 23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios 509 R. Steven Pappas SECTION VII FOOD ANALYSIS 529 24 Mass Spectrometry in Agriculture
Food
and Flavors: Selected Applications 531 Maciej Stobiecki
Piotr Kachlicki
and Henryk Jeleñ 25 Top-Down Proteomic Identifi cation of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS 559 Clifton K. Fagerquist and Omar Sultan SECTION VIII ENVIRONMENTAL 575 26 Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry 577 Wolfgang Schwack 27 Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry 593 Chongzheng Na and Terese M. Olson 28 Proton Transfer Reaction Mass Spectrometry (PTR-MS) 605 Yujie Wang
Chengyin Shen
Jianquan Li
Haihe Jiang
and Yannan Chu 29 Determination of Chlorinated Compounds in Dialysis Water and in Biological Fluids/Matrices 631 Diana Poli SECTION IX GEOLOGICAL 645 30 Mass Spectrometry Techniques for Analysis of Oil and Gas Trapped in Fluid Inclusions 647 Simon C. George
Herbert Volk
and Adriana Dutkiewicz 31 LA-MC-ICP-MS Applied to U-Pb Zircon Geochronology 675 Alain Cocherie and Michèle Robert 32 Hydrocarbon Processing 707 Maoqi Feng
Thomas Andrews
and Eloy Flores III 33 Hydrocarbon Processing: MALDI-MS of Polydisperse Hydrocarbon Samples 725 Alan A. Herod 34 Renewable Energy: Mass Spectrometry in Biofuel Research 749 Ingvar Eide and Kolbjørn Zahlsen SECTION X ARCHAEOLOGY 763 35 Mass Spectrometry in Archaeology 765 Robert Hedges and James McCullagh 36 Archaeometric Data from Mass Spectrometric Analysis of Organic Materials: Proteins
Lipids
Terpenoid Resins
Lignocellulosic Polymers
and Dyestuff 797 Maria Perla Colombini
Francesca Modugno
and Erika Ribechini 37 Laser Ablation ICP-MS in Archaeology 829 Hector Neff 38 Spatially Resolved MS in the Study of Art and Archaeological Objects 845 Giuseppe Spoto 39 Laser Ablation-Inductively Coupled Plasma Mass Spectrometry for the Investigation of Archaeological Samples 859 Martín Resano
Esperanza García-Ruiz
and Frank Vanhaecke SECTION XI SURFACE ANALYSIS 885 40 Mass Spectrometry in Semiconductor Research 887 Stefan Flege and Wolfgang Ensinger 41 Analysis of Thin and Thick Films 943 Philippe Le Coustumer
Patrick Chapon
Agnès Tempez
Yuriy Popov
George Thompson
Igor Molchan
Nicolas Trigoulet
Peter Skeldon
Antonino Licciardello
Nunzio Tuccitto
Ivan Delfanti
Katrin Fuhrer
Marc Gonin
James Whitby
Markus Hohl
Christian Tanner
Nerea Bordel Garcia
Lara Lobo Revilla
Jorge Pisonero
Rosario Pereiro
Cristina Gonzalez Gago
Alfredo Sanz Medel
Mihai Ganciu Petcu
Ani Surmeian
Constantin Diplasu
Andreea Groza
Norbert Jakubowski
Roland Dorka
Stela Canulescu
Johann Michler
Philippe Belenguer
Thomas Nelis
Abdellatif Zahri
Philippe Guillot
Laurent Thérèse
Arnaud Littner
Richard Vaux
Julien Malherbe
Frédéric Huneau
Fred Stevie
and Hugues François-Saint-Cyr 42 SIMS for Organic Film Analysis 961 Taoufi q Mouhib and Arnaud Delcorte 43 Ceramics: Contribution of Secondary Ion Mass Spectrometry (SIMS) to the Study of Crystal Chemistry of Mica Minerals 1017 Luisa Ottolini
Emanuela Schingaro
and Fernando Scordari SECTION XII POLYMERS 1061 44 ETV-ICPMS for Analysis of Polymers 1063 Maite Aramendía Marzo
Martín Resano
and Frank Vanhaecke 45 Polymers 1079 Maurizio S. Montaudo and Salvatore Battiato 46 Mass Spectroscopy in Polymer Research 1107 Jale Hacaloglu and Talat Yalcin 47 Laser Mass Spectrometry Applied to the Analysis of Polymers 1135 Jérôme Bour and David Ruch SECTION XIII ANALYTICAL TECHNIQUES 1143 48 Measuring Thermodynamic Properties of Metals and Alloys 1145 Evan H. Copland and Nathan S. Jacobson 49 High-Performance Thin-Layer Chromatography-Mass Spectrometry for Analysis of Small Molecules 1181 Gertrud E. Morlock 50 Laser Ionization Mass Spectrometry of Inorganic Ions 1207 Julius Pavlov and Athula B. Attygalle 51 Mass Spectrometry in the SSITKA Studies 1229 L.G. Pinaeva
E.M. Sadovskaya
A.P. Suknev
V.B. Goncharov
and B.S. Bal'zhinimaev 52 Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences 1257 Elena Crespo
Marco M.L. Steeghs
Simona M. Cristescu
and Frans J.M. Harren INDEX 1283