Igor A. Kaltashov, Stephen J. Eyles

Mass Spectrometry in Biophysics (eBook, PDF)

Conformation and Dynamics of Biomolecules

• Format: PDF

Produktbeschreibung

The first systematic summary of biophysical mass spectrometry techniques Recent advances in mass spectrometry (MS) have pushed the frontiers of analytical chemistry into the biophysical laboratory. As a result, the biophysical community's acceptance of MS-based methods, used to study protein higher-order structure and dynamics, has accelerated the expansion of biophysical MS. Despite this growing trend, until now no single text has presented the full array of MS-based experimental techniques and strategies for biophysics. Mass Spectrometry in Biophysics expertly closes this gap in the literature. Covering the theoretical background and technical aspects of each method, this much-needed reference offers an unparalleled overview of the current state of biophysical MS. Mass Spectrometry in Biophysics begins with a helpful discussion of general biophysical concepts and MS-related techniques. Subsequent chapters address: * Modern spectrometric hardware * High-order structure and dynamics as probed by various MS-based methods * Techniques used to study structure and behavior of non-native protein states that become populated under denaturing conditions * Kinetic aspects of protein folding and enzyme catalysis * MS-based methods used to extract quantitative information on protein-ligand interactions * Relation of MS-based techniques to other experimental tools * Biomolecular properties in the gas phase Fully referenced and containing a helpful appendix on the physics of electrospray mass spectrometry, Mass Spectrometry in Biophysics also offers a compelling look at the current challenges facing biomolecular MS and the potential applications that will likely shape its future.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 320
• Erscheinungstermin: 21. April 2005
• Englisch
• ISBN-13: 9780471705161
• Artikelnr.: 38212541

Autorenporträt

IGOR A. KALTASHOV, PhD, is currently an Assistant Professor in the Department of Chemistry at the University of Massachusetts, Amherst. STEPHEN J. EYLES, PhD, is a Lecturer in the Department of Polymer Science and Engineering and the Director of Mass Spectrometry and Molecular Weight Characterization Facility at the University of Massachusetts, Amherst.