Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds (eBook, PDF)

• Format: PDF

Produktbeschreibung

The recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, β-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for β-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose.

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Produktdetails

• Verlag: Cuvillier Verlag
• Seitenzahl: 144
• Erscheinungstermin: 6. Dezember 2018
• Englisch
• ISBN-13: 9783736989139
• Artikelnr.: 54744673