Metabolism, Pharmacokinetics and Toxicity of Functional Groups (eBook, PDF)

Impact of Chemical Building Blocks on ADMET
Redaktion: Smith, Dennis A

• Format: PDF

Produktdetails

• Verlag: RSC
• Seitenzahl: 544
• Erscheinungstermin: 9. April 2010
• Englisch
• ISBN-13: 9781849731102
• Artikelnr.: 44868015

Autorenporträt

Professor Dennis Smith has worked in the pharmaceutical industry for 32 years after gaining his Ph.D from the University of Manchester. For 20 years he was at Pfizer Global Research and Development, Sandwich where he was Vice President-Pharmacokinetics, Dynamics and Metabolism. For the past 2 years he has been a Pfizer Academic Research Fellow working on a part-time basis. His research interests and publications span all aspects of Drug Discovery and Development particularly where drug metabolism knowledge can impact on the design of more efficacious and safer drugs. During this 30-year span he has helped in the Discovery and Development of eight marketed NCEs. He has authored over 100 publications including two books.

Inhaltsangabe

Drug targets and their structural motifs
ADMET for the medicinal chemist
Carboxlic acids and their isosteres
Primary, secondary and tertiary amines and isosteres
Sulphonamide as an essential group
1, 2 and 3 ring phenyl and heterocyclic cores
Heterocycles and phenyls as essential pharmacophore groups
Peptides and peptidomimetic cores
Peptides and peptidomimetics as functional groups
Transition state functions
Alcohols and carbonyls
Future targets and chemistry needs