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This volume brings together the key research issues in clinical and laboratory science relating to metastasis in prostate cancer. Coverage ranges from the most fundamental aspects of the molecular biology of metastasis, to the patient in the clinic. The therapeutic approaches range from conventional drug design to immunogene therapy. Prostate cancer is an area of intense research effort, and this book provides a window on contemporary research in this important area.
This volume brings together the key research issues in clinical and laboratory science relating to metastasis in prostate cancer. Coverage ranges from the most fundamental aspects of the molecular biology of metastasis, to the patient in the clinic. The therapeutic approaches range from conventional drug design to immunogene therapy. Prostate cancer is an area of intense research effort, and this book provides a window on contemporary research in this important area.
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Inhaltsangabe
Chapter 1: Introduction: Metastasis as a Therapeutic Target Richard J. Ablin and Malcolm D. Mason
Chapter 2: The Natural History of Prostate Cancer David F. Penson and Peter C. Albertsen
Chapter 3: The Search for Genes Which Influence Prostate Cancer Metastasis: A Moving Target? Norman J. Maitland
Chapter 4: Polyunsaturated Fatty Acids and Prostate Cancer Metastasis Wen G. Jiang
Chapter 5: Role of Prostaglandin Synthesis and Cyclooxygenase-2 in Prostate Cancer and Metastasis Alaa F. Badawi
Chapter 6: Cell Cycle Regulation Ruchi M. Newman and Bruce R. Zetter
Chapter 7: Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity Mary J.C. Hendrix, Jun Luo, Elisabeth A. Seftor, Navesh Sharma, Paul M. Heidger Jr., Michael B. Cohen, Robert Bhatty, Jirapat Chungthapong, Richard E.B. Seftor, and David Lubaroff
Chapter 8: Orthotopic Metastatic Mouse Models of Prostate Cancer Robert M. Hoffman
Chapter 9: ß-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer Gaynor Davies, Gregory M. Harrison, and Malcolm D. Mason
Chapter 10: Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasis Gaynor Davies, Wen G. Jiang, and Malcolm D. Mason
Chapter 11: Matrix Degradation in Prostate Cancer Michael J. Wilson and Akhouri A. Sinha
Chapter 12: The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonates Noel W. Clarke and Herbert A. Fleisch
Chapter 13: Non-Steroidal Anti-Androgen Use as Part of Combined Androgen Blockade Therapy for Metastatic or Locally Advanced Prostate Cancer: a Review of the Evidence on Efficacy and Toxicity Mike Shelley, Charles Bennett, Derek Nathan, and Oliver Sartor
Chapter 14: Strategies for the Implementation of Chemotherapy and Radiotherapy Paula Scullin, Joe M. O'Sullivan, and Christopher C. Parker
Chapter15: Immuno-gene Therapy for Metastatic Prostate Cancer Takefumi Satoh, Terry L. Timme, Yehoshua Gdor, Brian J. Miles, Robert J. Amato, Dov Kadmon, and Timothy C. Thompson
Chapter 16: Distilling the Past - Envisioning the Future Richard J. Ablin and Malcolm D. Mason
Chapter 1: Introduction: Metastasis as a Therapeutic Target Richard J. Ablin and Malcolm D. Mason
Chapter 2: The Natural History of Prostate Cancer David F. Penson and Peter C. Albertsen
Chapter 3: The Search for Genes Which Influence Prostate Cancer Metastasis: A Moving Target? Norman J. Maitland
Chapter 4: Polyunsaturated Fatty Acids and Prostate Cancer Metastasis Wen G. Jiang
Chapter 5: Role of Prostaglandin Synthesis and Cyclooxygenase-2 in Prostate Cancer and Metastasis Alaa F. Badawi
Chapter 6: Cell Cycle Regulation Ruchi M. Newman and Bruce R. Zetter
Chapter 7: Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity Mary J.C. Hendrix, Jun Luo, Elisabeth A. Seftor, Navesh Sharma, Paul M. Heidger Jr., Michael B. Cohen, Robert Bhatty, Jirapat Chungthapong, Richard E.B. Seftor, and David Lubaroff
Chapter 8: Orthotopic Metastatic Mouse Models of Prostate Cancer Robert M. Hoffman
Chapter 9: ß-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer Gaynor Davies, Gregory M. Harrison, and Malcolm D. Mason
Chapter 10: Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasis Gaynor Davies, Wen G. Jiang, and Malcolm D. Mason
Chapter 11: Matrix Degradation in Prostate Cancer Michael J. Wilson and Akhouri A. Sinha
Chapter 12: The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonates Noel W. Clarke and Herbert A. Fleisch
Chapter 13: Non-Steroidal Anti-Androgen Use as Part of Combined Androgen Blockade Therapy for Metastatic or Locally Advanced Prostate Cancer: a Review of the Evidence on Efficacy and Toxicity Mike Shelley, Charles Bennett, Derek Nathan, and Oliver Sartor
Chapter 14: Strategies for the Implementation of Chemotherapy and Radiotherapy Paula Scullin, Joe M. O'Sullivan, and Christopher C. Parker
Chapter15: Immuno-gene Therapy for Metastatic Prostate Cancer Takefumi Satoh, Terry L. Timme, Yehoshua Gdor, Brian J. Miles, Robert J. Amato, Dov Kadmon, and Timothy C. Thompson
Chapter 16: Distilling the Past - Envisioning the Future Richard J. Ablin and Malcolm D. Mason
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