Mitochondrial heteroplasmy exists as a dynamically determined co-expression of inherited polymorphisms and somaticmutations in varying ratios within individual mitochondrial DNA Bacterial Genomes: Physical Structure and Analysis with repetitive patterns of tissue specificity.Mechanistically, carcinogenic cellular processes include profound alterations of normative mitochondrial function, notablydependence on aerobic and anaerobic glycolysis, and aberrant production and release of lactate, according to a classictheory. Within the translational context of human health and disease, the present review discusses the necessity ofestablishing critical foci designed to probe multiple biological roles of mitochondrial heteroplasmy in cancer biology.
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