Panos Macheras, Athanassios Iliadis

Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics (eBook, PDF)

Homogeneous and Heterogeneous Approaches

• Format: PDF

Produktbeschreibung

The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

This timely and useful book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 444
• Erscheinungstermin: 26. April 2006
• Englisch
• ISBN-13: 9780387319100
• Artikelnr.: 37287191

Inhaltsangabe

Part I: Basic Concepts.- The Geometry of Nature.- Diffusion and Kinetics.- Nonlinear Dynamics.- Part II: Modeling in Biopharmaceutics.- Drug Release.- Drug Dissolution.- Oral Drug Absorption.- Part III: Modeling in Pharmacokinetics.- Empirical Models.- Deterministic Compartmental Models.- Fractional Pharmacokinetics.- Modeling and Simulation in Bioequivalence.- Stochastic Compartmental Models.- Part IV: Modeling in Pharmacodynamics.- Classical Pharmacodynamics.- Nonclassical Pharmacodynamics.- Appendices.