Models and Algorithms for Genome Evolution (eBook, PDF)

Redaktion: Chauve, Cedric; Tannier, Eric; El-Mabrouk, Nadia

• Format: PDF

Produktbeschreibung

This authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution.

Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50^th anniversary of his first scientific article.

Topics and features:

• Discusses the development of the BLAST algorithm, model-based phylogeography techniques, and the double cut and join (DCJ) distance formula
• Reviews the reconstruction of evolutionary features of ancestral genomes in a known phylogeny, and presents integrative models of evolution
• Introduces algorithms to estimate alignment and phylogeny on ultra-large datasets, and an approach for using likelihood methods with rearrangement models
• Examines the impact of insertion and deletion variants in human biology, evolution and health
• Surveys novel and recent research on genomic distance and family-free genome comparison
• Describes consolidation methods for reconstruction of ancestralgene orders, and error detection in gene tree construction
• Investigates the genetic events recoverable from simulations of human population histories

The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas.

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Produktdetails

• Verlag: Springer London
• Seitenzahl: 328
• Erscheinungstermin: 17. September 2013
• Englisch
• ISBN-13: 9781447152989
• Artikelnr.: 43800916

Autorenporträt

Dr. Cedric Chauve is an associate professor at the Department of Mathematics of Simon Fraser University, Canada. Dr. Nadia El-Mabrouk is a full professor at the Computer Science Department of the University of Montreal, Canada. Dr. Eric Tannier is a researcher at the Bioinformatics and Evolutionary Genomics Group of Inria Grenoble - Rhône-Alpes, France.

Inhaltsangabe

Part I: Emergence of Standard Algorithms.- What's Behind Blast.- Forty Years of Model-Based Phylogeography.- How to Infer Ancestral Genome Features by Parsimony.- Duplication, Rearrangement and Reconciliation.- The Genesis of the DCJ Formula.- Part II: New Lights on Current Paradigms.- Large-Scale Multiple Sequence Alignment and Phylogeny Estimation.- Rearrangements in Phylogenetic Inference.- Status of Research on Insertion and Deletion Variations in the Human Population.- A Retrospective on Genomic Preprocessing for Comparative Genomics.- A Comparison of DCJ and Algebraic Distances.- Part III: Promising Directions.- Fractionation, Rearrangement, Consolidation, Reconstruction.- Error Detection and Correction of Gene Trees.- The Potential of Family-Free Genome Comparison.- Genetic History of Populations.