Modern Adaptive Randomized Clinical Trials (eBook, PDF)

Statistical and Practical Aspects
Redaktion: Sverdlov, Oleksandr

• Format: PDF

Produktbeschreibung

This book aids in identifying when to apply adaptive randomization designs in practice. Featuring contributions from statisticians, clinical trialists, and subject-matter experts in academia and industry, the text discusses restricted, covariate-adaptive, response-adaptive, and covariate-adjusted response-adaptive randomization designs, as well as randomized designs with treatment selection. It describes a successful implementation of a single pivotal phase II/III adaptive trial in infants with proliferating hemangioma, addresses practical aspects of phase II dose-ranging studies, and examines statistical monitoring and interim analysis issues in response-adaptive randomized clinical trials.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 533
• Erscheinungstermin: 30. Juni 2015
• Englisch
• ISBN-13: 9781482239898
• Artikelnr.: 43588204

Autorenporträt

Oleksandr Sverdlov

Inhaltsangabe

An Overview of Adaptive Randomization Designs in Clinical Trials. Efron's
Biased Coin Design Revisited: Statistical Properties, Randomization-Based
Inference, and Sequential Monitoring. Adaptive Biased Coins: Achieving
Better Balance without Compromising Randomness. Brick Tunnel and Wide Brick
Tunnel Randomization for Studies with Unequal Allocation. Development of
Novel Covariate-Adaptive Randomization Designs. Optimal Model-Based
Covariate-Adaptive Randomization Designs. Statistical Inference Following
Covariate-Adaptive Randomisation: Recent Advances. Covariate-Adaptive
Randomization with Unequal Allocation. Optimal Allocation Designs for a
Multi-Arm Multi-Objective Clinical Trial. Response-Adaptive Randomization:
An Overview of Designs and Asymptotic Theory. Statistical Inference
Following Response-Adaptive Randomization. Sample Size Re-Estimation in
Adaptively Randomized Clinical Trials with Missing Data. Some Caveats for
Outcome Adaptive Randomization in Clinical Trials. Efficient and Ethical
Adaptive Clinical Trial Designs to Detect Treatment-Covariate Interaction.
Longitudinal Covariate-Adjusted Response-Adaptive Randomization: Impact of
Missing Data. Targeted Covariate-Adjusted Response-Adaptive LASSO-Based
Randomized Controlled Trials. Covariate-Balanced Bayesian Adaptive
Randomization: Achieving Tradeoff Between Inferential and Ethical Goals in
Small and Moderate Size Trials. Multi-Arm Multi-Stage Designs for Clinical
Trials with Treatment Selection. Sequential Elimination in Multi-Arm
Selection Trials. Accounting for Parameter Uncertainty in Two-Stage Designs
for Phase II Dose-Response Studies. A Single Pivotal Adaptive Trial in
Infants with Proliferating Hemangioma: Rationale, Design Challenges,
Experience, and Recommendations. Practical Implementation of Dose-Response
Adaptive Trials. Statistical Monitoring of Data in Response-Adaptive
Randomized Clinical Trials.