Michael P. Czech

Molecular Basis of Insulin Action (eBook, PDF)

• Format: PDF

Produktbeschreibung

One day, in a moment of weakness, I fell prey to the temptation to organize and edit this volume on the mechanism of insulin action. The major reason for attempting to resist, of course, is the amazing speed at which advances are being made in this field. The usefulness of books such as this is often quickly compromised by new findings obtained during and just after publication. Happily for the contributors to this volume and myself, this unfortunate fate does not appear to be in store for us. New and important findings will undoubtedly continue to flow in this field during the next few years, but I believe this will increase rather than decrease the usefulness of this volume. As a matter of fact, as we go to press, I am delighted both that I was tempted and that I failed to resist. There are two basic reasons for my enthusiasm about this book, and they both relate to this issue of timeliness. First, each of the contributors has had an opportunity to update the scientific content of the various chapters only a few months before actual publication of this volume. The material presented in this volume is, at publication, contemporary with the current original literature. This volume thus provides an ex cellent framework for assessing new discoveries in this field for some time to come.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 474
• Erscheinungstermin: 11. November 2013
• Englisch
• ISBN-13: 9781468448740
• Artikelnr.: 43993739

Inhaltsangabe

1. Subunit Structure and Regulation of the Insulin-Receptor Complex.- 2. Immunochemical Characterization of Receptors for Insulin and Insulinlike Growth Factor-I.- 3. The Metabolism of Insulin Receptors: Internalization, Degradation, and Recycling.- 4. The Insulin Receptor Protein Kinase.- 5. What Do Receptor Kinases Do?.- 6. The Role of Calcium in the Transduction of Insulin Action.- 7. Actions of Insulin on Electrical Potential Differences across Cell Membranes.- 8. Effect of Insulin on the Membrane Potentials of Rat White Epididymal Fat Cells.- 9. The Case for Intracellular pH in Insulin Action.- 10. Multiple Intracellular Peptide Mediators of Insulin Action.- 11. Intracellular Mediators of Insulin Action.- 12. Intracellular Mediators of Insulin Action.- 13. The Molecular Mechanism by Which Insulin Activates Glycogen Synthase in Mammalian Skeletal Muscle.- 14. Skeletal Muscle Glycogen Synthase: Hormonal Regulation.- 15. Insulin Regulation of Glycogen Synthase in Rat Heart and Liver.- 16. Protein Phosphorylations As a Mode of Insulin Action.- 17. Role of Phosphorylation in the Regulation of Acetyl CoA Carboxylase Activity.- 18. Regulation of Acetyl CoA Carboxylase by Insulin and Other Hormones.- 19. Direct Regulation of Nuclear Functions by Insulin: Relationship to mRNA Metabolism.- 20. Hormonal Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression.- 21. Hormonal Regulation of the Expression of the Genes for Malic Enzyme and Fatty Acid Synthase.- 22. Regulation of Pyruvate Kinase Gene Expression by Hormones and Developmental Factors.- 23. Hexose Transport Regulation by Insulin in the Isolated Rat Adipose Cell.- 24. Insulin-Dependent Apparent Translocation of Glucose Transport Activity: Studies by the Reconstitution Method.- 25. Insulin Action on Membrane Components: The Glucose Transporter and the Type II Insulinlike Growth Factor Receptor.- 26. Insulin Action on the (Na+,K+)ATPase.