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This volume in the Human Molecular Genetics series is an invaluable text for endocrinologists wishing to update their knowledge. It also provides an excellent grounding in the basic genetics of molecular endocrinology and relevant analytical techniques.
This volume in the Human Molecular Genetics series is an invaluable text for endocrinologists wishing to update their knowledge. It also provides an excellent grounding in the basic genetics of molecular endocrinology and relevant analytical techniques.
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Autorenporträt
Department of Molecular Pathology, Windeyer Institute of Medical Sciences, London, UK. Department of Medicine, UCL Medical School, Middlesex Hospital, London, UK.
Inhaltsangabe
Contributors Abbreviations Single letter codes for amino acids Preface 1 Basis of gene structure and function. S.M. Farrow Introduction Gene transcription to polypeptide synthesis Gene transcription Regulation of gene transcription Post transcriptional regulation of gene expression Translational regulation Concluding remarks References 2 Molecular analysis of gene structure and function. P.M. Brickell Introduction Detecting mutations in genes Analysing the regulation of gene expression Molecular 'fingerprinting' of DNA and RNA populations Isolating differentially expressed genes by subtractive hybridization Analysing gene function in transgenic mice Identifying protein protein interactions Conclusion References 3 Mechanism of action of peptide hormones. S. Barker Introduction Receptor protein structure function relationships Signal transduction pathways Regulation of the response Future perspectives References 4 The steroid hormone superfamily of receptors. VK.K. Chatterjee, R.J. Clifton Bligh and C. Matthews Introduction Structure function relationships in nuclear receptors Nuclear hormone receptor mutations and disease Nuclear receptor knockouts Conclusions References 5 Molecular insights into mechanisms regulating glucose homeostasis. PR. Shepherd Introduction The role of the endocrine pancreas The role of liver, muscle and adipose tissue in the regulation of glucose homeostasis Role of insulin signalling pathways in maintaining glucose homeostasis Integration of the individual components regulating glucose homeostasis Conclusion References 6 PTHrP in calcium homeostasis. T.J. Martin and M. T. Gillespie Introduction Hypercalcaemia in cancer the role of PTHrP Characterization of PTHrP The PTHrP gene Regulation of PTHrP expression PTH, PTHrP and calcium receptors Tissue distribution of PTHrP its functions as a cytokine PTHrP and placental calcium transport PTHrP in lactation PTHrP in bone Receptor related genetic disorders References 7 Molecular biology of growth. W.R. Baumbach, B. Bingham and JR. Zysk The growth hormone axis The hypothalamic hormones GRF and SRIF and their receptors GH GH receptors and binding proteins IGF I, its receptor and binding proteins Concluding remarks References 8 Molecular biology of steroid biosynthesis. G. Rumsby Introduction The enzymes Regulation of steroidogenesis Developmental regulation of steroidogenesis Conclusion References 9 Genetics of hypertension and the renin angiotensin aldosterone system. PC. White Introduction Angiotensinogen Steroid 11 (3 hydroxylase isozymes llp Hydroxysteroid dehydrogenase The amiloride inhibitable epithelial sodium channel References 10 Sex differentiation, gonadal development and reproductive function.G.S. Conway Introduction Sex differentiation and gonadal development The hormonal control of reproductive function Conclusions References Index.
Contributors Abbreviations Single letter codes for amino acids Preface 1 Basis of gene structure and function. S.M. Farrow Introduction Gene transcription to polypeptide synthesis Gene transcription Regulation of gene transcription Post transcriptional regulation of gene expression Translational regulation Concluding remarks References 2 Molecular analysis of gene structure and function. P.M. Brickell Introduction Detecting mutations in genes Analysing the regulation of gene expression Molecular 'fingerprinting' of DNA and RNA populations Isolating differentially expressed genes by subtractive hybridization Analysing gene function in transgenic mice Identifying protein protein interactions Conclusion References 3 Mechanism of action of peptide hormones. S. Barker Introduction Receptor protein structure function relationships Signal transduction pathways Regulation of the response Future perspectives References 4 The steroid hormone superfamily of receptors. VK.K. Chatterjee, R.J. Clifton Bligh and C. Matthews Introduction Structure function relationships in nuclear receptors Nuclear hormone receptor mutations and disease Nuclear receptor knockouts Conclusions References 5 Molecular insights into mechanisms regulating glucose homeostasis. PR. Shepherd Introduction The role of the endocrine pancreas The role of liver, muscle and adipose tissue in the regulation of glucose homeostasis Role of insulin signalling pathways in maintaining glucose homeostasis Integration of the individual components regulating glucose homeostasis Conclusion References 6 PTHrP in calcium homeostasis. T.J. Martin and M. T. Gillespie Introduction Hypercalcaemia in cancer the role of PTHrP Characterization of PTHrP The PTHrP gene Regulation of PTHrP expression PTH, PTHrP and calcium receptors Tissue distribution of PTHrP its functions as a cytokine PTHrP and placental calcium transport PTHrP in lactation PTHrP in bone Receptor related genetic disorders References 7 Molecular biology of growth. W.R. Baumbach, B. Bingham and JR. Zysk The growth hormone axis The hypothalamic hormones GRF and SRIF and their receptors GH GH receptors and binding proteins IGF I, its receptor and binding proteins Concluding remarks References 8 Molecular biology of steroid biosynthesis. G. Rumsby Introduction The enzymes Regulation of steroidogenesis Developmental regulation of steroidogenesis Conclusion References 9 Genetics of hypertension and the renin angiotensin aldosterone system. PC. White Introduction Angiotensinogen Steroid 11 (3 hydroxylase isozymes llp Hydroxysteroid dehydrogenase The amiloride inhibitable epithelial sodium channel References 10 Sex differentiation, gonadal development and reproductive function.G.S. Conway Introduction Sex differentiation and gonadal development The hormonal control of reproductive function Conclusions References Index.
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