Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research (eBook, ePUB)

Redaktion: Gerlai, Robert T.

• Format: ePub

Produktbeschreibung

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing.

Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists.

• Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials
• Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior
• Written and edited by leading international experts

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 708
• Erscheinungstermin: 24. April 2018
• Englisch
• ISBN-13: 9780128041161
• Artikelnr.: 50521709

Inhaltsangabe

Section I: Neuroinformatics, Computational Models and Data Analysis
1. Neurological Biomarkers and NeuroInformatics: The Role of The Virtual
Brain
2. Informatics for Interoperability of Molecular-Genetic and
Neurobehavioral Databases
3. The Allen Brain Atlas: Towards understanding brain behavior and function
through data acquisition, visualization, analysis and integration
4. ExAtlas: On-line tool to integrate gene expression and gene set
enrichment analyses
5. Computational Models: How do they help to understand neurological
diseases?
6. The Use of Recombinant Inbred Strains in Systems Genetics and Functional
Analyses in Behavioral Pharmacology
Section II. Searching for New Genes: Natural Genetic Variation
7. Spontaneous versus induced mutations: Conceptual and methodological
considerations for the neurobehavioral geneticist
8. Reduced complexity cross design for behavioral genetics
9. Collaborative Cross as the next-generation mouse genetic reference
population designed for dissecting complex traits
10. Discovery of novel genes and other lineage-specific features through
comparative genomics
11. Using signatures of directional selection to guide discovery
Section III: Discovery of New Genes and New Functions of Genes Using Gene
Expression Analyses
12. Using Transcriptomics to Study Behavior
13. Genes, Behavior and Next-Generation Sequencing - The First Ten Years
14. Abnormal social behaviors and dysfunction of autism-related genes
associated with daily agonistic interactions in mice
15. Epigenetic mechanisms of learning and memory
Section IV: Discovery of Genes and Biological Mechanisms: Forward Genetics
and Other Screening-Based Methods
16. Systematic screens in zebrafish shed light on cellular and molecular
mechanisms of complex brain phenotypes
17. The transition of zebrafish functional genetics from random mutagenesis
to targeted integration
Section V: Manipulating Known Genes to Understand Biological Function:
Reverse Genetics
18. Molecular Techniques Used to Explore Glutamate Receptors in Synaptic
Plasticity and Memory
19. Using Herpes Simplex Virus Type-1-Based Amplicon Vectors for
Neuroscience Research and Gene Therapy of Neurological Diseases
20. Cre-lox neurogenetics: history, present and future
21. Functional Analysis of Proteins Involved in Neurodegeneration Using the
Model Organism Dictyostelium: Alzheimer's, Huntington's and Batten Disease
22. The role of human endogenous retroviruses (HERVs) in the pathologies of
nervous system
23. Optogenetics dissection of sleep circuits and functions
24. The use of DREADDs for dissecting the contribution of cellular and
neural circuit mechanisms in models of neurodegenerative disease
Section VI: Ethical Considerations
25. Genes and human behavior: Ethical implications
26. Ethical Considerations for Animal use in Behavioral and Neural Research