Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research (eBook, ePUB)

Redaktion: Gerlai, Robert T.

• Format: ePub

Produktbeschreibung

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing.

Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists.

• Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials
• Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior
• Written and edited by leading international experts

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 708
• Erscheinungstermin: 24. April 2018
• Englisch
• ISBN-13: 9780128041161
• Artikelnr.: 50521709

Inhaltsangabe

Section I: Neuroinformatics, Computational Models and Data Analysis 1.
Neurological Biomarkers and NeuroInformatics: The Role of The Virtual Brain
2. Informatics for Interoperability of Molecular-Genetic and
Neurobehavioral Databases 3. The Allen Brain Atlas: Towards understanding
brain behavior and function through data acquisition, visualization,
analysis and integration 4. ExAtlas: On-line tool to integrate gene
expression and gene set enrichment analyses 5. Computational Models: How do
they help to understand neurological diseases? 6. The Use of Recombinant
Inbred Strains in Systems Genetics and Functional Analyses in Behavioral
Pharmacology Section II. Searching for New Genes: Natural Genetic Variation
7. Spontaneous versus induced mutations: Conceptual and methodological
considerations for the neurobehavioral geneticist 8. Reduced complexity
cross design for behavioral genetics 9. Collaborative Cross as the
next-generation mouse genetic reference population designed for dissecting
complex traits 10. Discovery of novel genes and other lineage-specific
features through comparative genomics 11. Using signatures of directional
selection to guide discovery Section III: Discovery of New Genes and New
Functions of Genes Using Gene Expression Analyses 12. Using Transcriptomics
to Study Behavior 13. Genes, Behavior and Next-Generation Sequencing - The
First Ten Years 14. Abnormal social behaviors and dysfunction of
autism-related genes associated with daily agonistic interactions in mice
15. Epigenetic mechanisms of learning and memory Section IV: Discovery of
Genes and Biological Mechanisms: Forward Genetics and Other Screening-Based
Methods 16. Systematic screens in zebrafish shed light on cellular and
molecular mechanisms of complex brain phenotypes 17. The transition of
zebrafish functional genetics from random mutagenesis to targeted
integration Section V: Manipulating Known Genes to Understand Biological
Function: Reverse Genetics 18. Molecular Techniques Used to Explore
Glutamate Receptors in Synaptic Plasticity and Memory 19. Using Herpes
Simplex Virus Type-1-Based Amplicon Vectors for Neuroscience Research and
Gene Therapy of Neurological Diseases 20. Cre-lox neurogenetics: history,
present and future 21. Functional Analysis of Proteins Involved in
Neurodegeneration Using the Model Organism Dictyostelium: Alzheimer's,
Huntington's and Batten Disease 22. The role of human endogenous
retroviruses (HERVs) in the pathologies of nervous system 23. Optogenetics
dissection of sleep circuits and functions 24. The use of DREADDs for
dissecting the contribution of cellular and neural circuit mechanisms in
models of neurodegenerative disease Section VI: Ethical Considerations 25.
Genes and human behavior: Ethical implications 26. Ethical Considerations
for Animal use in Behavioral and Neural Research