Molecular Oncology Testing for Solid Tumors (eBook, PDF)

A Pragmatic Approach
Redaktion: Idowu, Michael Ola; Garrett, Carleton Theodore; Dumur, Catherine Isabelle

• Format: PDF

Produktbeschreibung

This text is designed to present an up-to-date practical approach to molecular testing in an easy to understand format. Emphasis is placed on molecular testing for solid tumors, while underscoring the following: i) the crucial role of pathologists in ensuring specimen adequacy for molecular testing; ii) current molecular assays/platforms (including next-generation sequencing); iii) clinical utility and limitations of biomarkers to enable effective communication with clinicians; iv) the importance of quality assurance metrics to ensure accurate and reproducible results; v) pitfalls in test interpretation (that may lead to False Positive or False Negative interpretations); vi) importance of using standard nomenclature, including exercises on variant (mutation) description; vii) regulatory affairs, coding and reimbursement.

The uniqueness of this text is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant qualityassurance issues to ensure focused and efficient presentation of information.

Molecular Oncology Testing for Solid Tumors will enable readers to easily understand the Ordering, Processing, Interpretation, Reporting and the clinical Application (OPIRA) process of molecular testing or biomarkers.

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Produktdetails

• Verlag: Springer International Publishing
• Seitenzahl: 742
• Erscheinungstermin: 18. August 2015
• Englisch
• ISBN-13: 9783319163048
• Artikelnr.: 43799256

Inhaltsangabe

Part I. Overview of Basic Cellular Biology.- 1. Normal molecular biology and definition of terms.- 2. Pathologic changes: Chromosomes, genes, DNA, RNA and proteins.- 3. Standard nomenclature - introduction and brief overview.- Part II. Molecular Oncology Methodology.- 4. General principles of Oncology testing.- 5. Molecular methodologies.- 6. General principles of validating a molecular test.- Part III. Molecular testing in Solid Tumors.- 7. Lung and mediastinum.- 8. Breast.- 9. Head and neck (salivary glands).- 10. Thyroid and parathyroid (endocrine).- 11. Gastrointestinal and Pancreatobiliary.- 12. Soft tissue.- 13. Genitourinary system.- 14. Central Nervous System.- 15. Skin and adnexa.- 16. Common Hereditary Cancer Syndromes.- Part IV. The future is here.- 17. Application of next generation sequencing.- Part V. Quality Assurance and Regulatory affairs.- 18. Quality Assurance - pre-analytic, analytic and post-analytic.- 19. Regulatory affairs (including accreditation).- 20. Coding and re-imbursement.

Rezensionen

"This book provides an up-to-date, practical approach to molecular oncology testing for solid tumors. ... This is a practical reference for practicing pathologists, oncologists, internists, medical geneticists, pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, scientists who undertake disease-related basic science and translational research, as well as medical technologists." (Michel Nasr, Doody's Book Reviews, November, 2015)