More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, 2 Volume Set (eBook, ePUB)

Redaktion: Faisca Phillips, Ana Maria

• Format: ePub

Produktbeschreibung

More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles An authoritative collection of resources discussing the latest trends in the synthesis of nonaromatic nitrogen heterocycles Widely distributed in nature, nitrogen heterocycles are extremely common in synthetic substances found in pharmaceuticals, agrochemicals, and materials. The literature is evolving rapidly and explores newly emerging structures and medicines. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles offers R&D professionals the opportunity to easily access a collection of the latest relevant research in the area. In the second two-volume set of this practical reference distinguished researcher Dr. Ana Maria M. M. Faisca Phillips delivers a collection of resources focusing on the newest and most widely applicable trends emerging in synthetic strategies for nonaromatic nitrogen heterocycles. With coverage of topics including organocatalysis, cascade reactions, flow chemistry in synthesis, cycloaddition reactions, metathesis, cross-coupling reactions, and electrochemistry, the book provides quick access to critical new avenues of synthesis. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 also offers readers: * A thorough introduction to recent advances in the design and synthesis of cyclic peptidomimetics * Comprehensive explorations of fused heterocycles and transition metal promoted synthesis of isoindoline derivatives * Practical discussions of 1,4-diazepane ring-based systems and recent advances in the synthesis of azepane-based compounds * In-depth examinations of strained aziridinium ions, asymmetric organocatalysis in alternative media, and the electrochemical synthesis of non-aromatic N-heterocycles Perfect for academic and industrial researchers in organic chemistry and synthesis, organometallic chemistry, pharmaceutical chemistry catalysis, and sustainable chemistry, More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 is an indispensable reference for anyone seeking an authoritative source of information on new and emerging trends in synthesis.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 752
• Erscheinungstermin: 11. April 2022
• Englisch
• ISBN-13: 9781119757146
• Artikelnr.: 63894607

Autorenporträt

Ana Maria M.M. Faisca Phillips, PhD, is Researcher at the Coordination Chemistry and Catalysis Group, Centro de Química Estrutural, Instituto Superior Técnico Universidade de Lisboa.

Inhaltsangabe

List of Contributors

Preface

List of Common Abbreviations

PART 1: CASCADE REACTIONS

1 Unity is Strength: The Case of Cascade Reactions Combined with C-H Activation 1

Emanuele Casali, Ervis Saraci and Giuseppe Zanoni

1.1 Introduction

1.2 Rhodium Promoted Reactions

1.3 Palladium Promoted Reactions

1.4 Ruthenium Promoted Reactions

1.5 Cobalt Promoted Reactions

1.6 Miscellaneous

References

2 Chemo-enzymatic Cascade Reactions for the Synthesis of Chiral Intermediates

and Nonaromatic Nitrogen Heterocycles

Rodrigo O.M.A. de Souza, Raquel A.C. Leao, Marcelo A. Nascimento, Alexandre de S. França, Amanda S. de Miranda, Ivaldo I. Junior

2.1 Introduction

2.2 C-N Bond Construction Enzymes

2.3 C-N Deracemization Enzymes

2.4 Cascade Reactions

2.4.1 Enzymatic Cascade Reactions

2.4.2 Chemoenzymatic Cascade Reactions

References

3 Asymmetric Organocatalytic Cascade Reactions for the Synthesis of Nitrogen Heterocycles

A. M. M. M. Faisca Phillips

3.1 Introduction

3.2 Three-membered Ring Heterocycles: Aziridines

3.3 Four-membered Ring Heterocycles: The ß-lactams

3.4 Five-membered Rings

3.4.1 Pyrrolidines

3.4.2 Pyrrolidinones ( -Lactams)

3.4.3 Isoindolinones and Spirooxindoles

3.5 Six-membered Rings

3.5.1 Piperidines, Dihydropyridines and Tetrahydropyridines

3.5.2 Piperidinones ( -lactams)

3.5.3 Dihydropyridinones

3.5.4 Tetrahydroquinolines, Dihydroquinolines and Related Substances

3.5.5 Hexahydropyridazines and Pyrimidinones

3.6 Pyrrolo[3,2,1-ij]quinolines

3.7 Cyclic Sulfamidates

3.8 Miscellaneous

Conclusion

References

PART 2: SELECTED REACTIONS FOR THE SYNTHESIS OF NITROGEN HETEROCYCLES

4 Synthesis of Nitrogen-Heterocycles Based on N-Heterocyclic Carbene Organocatalysis

Hideto Miyabe

4.1 Introduction

4.2 NHC-catalyzed Cyclization

4.3 NHC-catalyzed Annulation

4.3.1 [3 + 2] Annulation

4.3.2 [4 + 2] Annulation

4.3.3 [3 + 3] Annulation

4.3.4 [4 + 3] Annulation

4.3.5 [2 + 2] Annulation

4.4 Oxidative NHC-catalyzed Annulation

4.4.1 Oxidative [3 + 2] Annulation

4.4.2 Oxidative [4 + 2] Annulation

4.4.3 Oxidative [3 + 3] Annulation

4.4.4 Oxidative [4 + 3] Annulation

4.4.5 Oxidative [2 + 2] Annulation

4.5 Asymmetric Dearomatization

4.6 Cooperative Catalysis of NHC and Transition-Metal Catalysts

4.7 Other NHC-catalyzed Reactions

4.8 Conclusion and Outlook

References

5 Synthesis of N-Heterocycles via [3 + n] Cycloaddition Reactions of Vinyl Metal Carbene Intermediates

Ming Bao, Su Zhou, and Xinfang Xu

5.1 Introduction

5.2 [3 + 1]-Cycloaddition

5.3 [3 + 2]-Cycloaddition

5.4 [3 + 3]-Cycloaddition

5.4.1 [3 + 3]-Cycloaddition with Nitrone

5.4.2 [3 + 3]-Cycloaddition with Azomethine Imines

5.4.3 [3 + 3]-Cycloaddition with Other 1,3-Dipoles

5.5 [3 + 4]-Cycloaddition

5.5.1 [3 + 4]-Cycloaddition with N-Heterocycles

5.5.2 [3 + 4]-Cycloaddition with alpha,beta-Unsaturated Imines

5.5. Other Types of [3 + 4]-Cycloadditions

5.6 [3 + 5]-Cycloaddition

5.7 Intramolecular Cyclization via Carbe