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"This monograph is intended for researchers interested in medical robotics where images are used to guide a surgical device around anatomical obstacles to reach a clinical target or attain a clinical goal. Three key algorithmic problems are addressed, compensation for deformations that may occur when surgical devices contact soft tissue, uncertainty in the response of surgical devices to command actions, and path optimization to achieve the specific goal while minimizing negative side effects." (IEEE Control Systems Magazine, Vol. 30, April, 2010)