Mutagenesis of the Mouse Genome (eBook, PDF)

Redaktion: Justice, Monica; Bedell, Mary

• Format: PDF

Produktbeschreibung

The Human Genome Project has changed our approach to biology. Sequence data are being acquired from multiple organisms at a phenomenal pace and mutagenesis is being carried out in many model organisms to discover gene functions. The mouse is the first mammal to be subjected to large-scale mutagenesis, for its biological similarities to the human will permit key discoveries. Mutagenesis of the Mouse Genome focuses on articles relevant to mouse chemical mutagenesis, and is dedicated to the memory of the mutagenesis pioneer, William L. Russell. Monica Justice provides an overview of the history of the Human Genome Project and use of the mouse as the primary organism for the functional annotation of the mammalian genome. With special articles by Jean-Louis Guenet describing the history and development of mouse chemical mutagenesis, Liane Russell analyzing decades of data on DNA damage after chemical treatment, Steven Barthold describing how environment can affect mouse phenotypes, Miriam Meisler summarizing the power of allelic series, Molly Bogue describing the variation in mouse inbred strains, and Mark Strivens and Janan Eppig showing how informatics tools can aid in functional analysis, this book is designed to be a handbook and reference guide for mouse genetics in the post-genome era.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 98
• Erscheinungstermin: 12. November 2007
• Englisch
• ISBN-13: 9781402050572
• Artikelnr.: 43604604

Autorenporträt

Monica Justice, Baylor College of Medicine, Houston, TX, USA / Mary Bedell, University of Georgia, Athens, GA, USA

Inhaltsangabe

From the Atomic Age to The Genome Project.- Chemical mutagenesis of the mouse genome: an overview.- Effects of male germ-cell stage on the frequency, nature, and spectrum of induced specific-locus mutations in the mouse.- Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions.- Towards a mutant map of the mouse - new models of neurological, behavioural, deafness, bone, renal and blood disorders.- Implementing large-scale ENU mutagenesis screens in North America.- Genetic mapping and ENU mutagenesis.- The Mouse Phenome Project.- Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes.- Visualizing the laboratory mouse: capturing phenotype information.

Rezensionen

From the reviews:

"Mutagenesis of the Mouse Genome is a collection of papers originally presented at the Second Georgia Genetics Symposium in 2002 and printed in a special issue of Genetica in 2004. ... this volume collects in one place much information that will prove valuable to current and prospective users of the wealth of mice produced by chemical mutagenesis. ... this book provides a strong introduction to the origins, acquisition and use of mutagenized mice." (Elissa J. Chesler, Genes, Brain and Behaviour, Vol. 5, 2006)