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NANOCARRIER VACCINES This book details the benefits, restrictions, and types of nanoparticles used in the creation of vaccines for the treatment and prevention of illnesses. In nanomedicine and nano-delivery systems, materials in the nanoscale range are used as diagnostic instruments or to administer therapeutic compounds to particular targeted regions in a controlled manner. By delivering precise medications to specified locations and targets, nanotechnology provides several advantages in treating chronic human illnesses. The use of nanomedicine (including chemotherapeutic medicines,…mehr
NANOCARRIER VACCINES This book details the benefits, restrictions, and types of nanoparticles used in the creation of vaccines for the treatment and prevention of illnesses. In nanomedicine and nano-delivery systems, materials in the nanoscale range are used as diagnostic instruments or to administer therapeutic compounds to particular targeted regions in a controlled manner. By delivering precise medications to specified locations and targets, nanotechnology provides several advantages in treating chronic human illnesses. The use of nanomedicine (including chemotherapeutic medicines, biological agents, immunotherapeutic agents, etc.) in the treatment of various diseases has recently seen many notable applications. This book aims to be a single source material for understanding all the current and novel advancements in the field of nanotechnology. In this groundbreaking book the reader will find: * biodegradable and non-biodegradable formulations and properties such as size, shape, charge, inertness, efficacy, morphology, and more; * show how different nanoparticles, such as lipid-based, viral vector-based, and metal, uphold very significant properties individually, suggesting applicability in various management tactics; * examines how genetic information-carrying entities are becoming the norm for eradicating some diseases; * gathers an exhaustive amount of information on routes of administration such as the oral route, mucosal immunity, intramuscular, subcutaneous, and intradermal; * explores the legal regulations for nanotechnology-based approaches. Audience Researchers and pharmacy students in biomedical engineering and chemical engineering, biotechnology, as well as pharmaceutical and biopharmaceutical industry engineers working in drug discovery, chemical biology, computational chemistry, medicinal chemistry, and bioinformatics.
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Autorenporträt
Vivek P. Chavda is an assistant professor in the Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad, India. He is BPharm and MPharm Gold medalist at Gujarat Technological University. Before joining academia, he served as an R & D scientist in the biologics industry for almost 8 years with many successful regulatory filings. He has more than 150 national and international publications, 25 book chapters, and one patent in the pipeline. His research interests include the development of biologics processes and medical device development, nano-diagnostics, and non-carrier formulations, long-acting parenteral formulations, and nano-vaccines. Professor Vasso Apostolopoulos is the Pro Vice-Chancellor, Research Partnerships at Victoria University, Australia. She received her PhD majoring in immunology in 1995 from the University of Melbourne, and the Advanced Certificate in Protein Crystallography from Birkbeck College, University of London. In response to the Covid-19 global emergency, Vasso and her team in VU's immunology and translational research focused their efforts on investigating and working on vaccines and drugs to treat the virus. Professor Vasso Apostolopoulos is a world-renowned researcher who has been recognized with over 100 awards for the outstanding results of her research. She has more than 450 international publications to her credit.
Inhaltsangabe
Preface xxi
Part 1 General 1
1 History of Nanoparticles 3 Keshava L. Jetha, Arya Vyas, Divya Teli, Amit Chaudhari, Riyansi Satasiya, Vishwa Patel, Shailvi Soni, Shail Modi and Vasso Apostolopoulos
1.1 Introduction 4
1.2 History of Nanoparticles 5
1.3 Modern Development of Nanoparticles 8
1.4 Type of Nanoparticles 10
1.5 Properties of Nanoparticles 13
1.6 Importance of Nanoparticles 15
1.7 Conclusion and Future Prospect 18
2 Composition of Nanoparticles 25 Amit Chaudhari, Palak Vadodariya, Arya Vyas, Disha Patel and Divya Teli
2.1 Introduction 25
2.2 Types of Nanoparticles 27
2.3 Composition of Nanoparticles 40
2.4 Synthesis of Nanoparticles 45
2.5 Nanoparticle Characterization by Various Instrumental Techniques 50
2.6 Understanding Nanotoxicity: Potential Risks and Implications 53
2.7 Conclusion 54
3 Nanotechnology and Vaccine Development 63 Keshava L. Jetha, Praful D. Bharadia and Manish P. Patel
3.1 Introduction 63
3.2 Overview of Vaccine Development 64
3.3 Advantages of Nanoparticles in Vaccine Delivery 66
3.4 Types of Nanoparticles as Vaccine Carriers 67
3.5 Development of Nanoparticle-Based Vaccine 70
3.6 Adjuvants and their Role in Vaccine Development 72
3.7 Nanoscale Adjuvants 74
3.8 Advantages 75
3.9 Techniques for Nanoscale Adjuvants 76
3.10 Route of Administration for Vaccines 77
3.11 Recent Advances in Nanotechnology-Based Vaccines 79
3.12 The Regulatory Perspective of Nanoparticle-Based Vaccine Development 80
3.13 Future Prospects 81
3.14 Conclusion 84
4 Nanoparticle Formulations: A Sustainable Approach to Biodegradable and Non-Biodegradable Products 95 Amandeep Singh, Shreni Parikh, Nutan Sethi, Sachin Patel, Nrupal Modi and Kaushika Patel
4.1 Introduction 96
4.2 Types of Nanoparticles 96
4.3 Preparation of Nanoparticles 100
4.4 Factors Affecting Selection of Method 100
4.5 Polymers Used in NP Formulation 107
4.6 Nanoparticle Formulations Based on Biodegradable Polymers 107
4.7 Nanoparticle Formulations Based on Non-Biodegradable Polymers 115
4.8 Nanoparticle Formulations Based on Natural Polymers 118
4.9 Challenges in NPs from Laboratory to Industrial Scale-Up 121
5 Nanoparticle Properties: Size, Shape, Charge, Inertness, Efficacy, Morphology 153 Kajal P. Baviskar, Brijesh M. Shah, Anjali P. Bedse, Shilpa S. Raut, Suchita P. Dhamane and Dhara J. Dave
5.1 Introduction 154
5.2 Applications of Nanoparticle Formulations 155
5.3 Interaction with Cells 157
5.4 Properties of Nanoparticles 159
5.5 Role of Physicochemical Properties in Nanoparticle Toxicity 174
5.6 Conclusion 177
Part 2 Nanoparticles to Deliver Antigen 193
6 Viral Vector-Based Nanoparticles 195 Suneetha Vuppu, Vivek P. Chavda, Toshika Mishra, Oishani Sengupta, Anand Sairam, Paridhi Soni, Mohit Joshi, Bhumi Bhalodiya and Raj V.
6.1 Introduction 196
6.2 Characteristics of Viral Vector-Based Nanoparticles 197
6.3 Applications 199
6.4 Novel Advancements in Applications of Viral Nanoparticles 225
6.5 Limitations and Prospects of Viral Vector-Based Nanoparticle Approach 233
1 History of Nanoparticles 3 Keshava L. Jetha, Arya Vyas, Divya Teli, Amit Chaudhari, Riyansi Satasiya, Vishwa Patel, Shailvi Soni, Shail Modi and Vasso Apostolopoulos
1.1 Introduction 4
1.2 History of Nanoparticles 5
1.3 Modern Development of Nanoparticles 8
1.4 Type of Nanoparticles 10
1.5 Properties of Nanoparticles 13
1.6 Importance of Nanoparticles 15
1.7 Conclusion and Future Prospect 18
2 Composition of Nanoparticles 25 Amit Chaudhari, Palak Vadodariya, Arya Vyas, Disha Patel and Divya Teli
2.1 Introduction 25
2.2 Types of Nanoparticles 27
2.3 Composition of Nanoparticles 40
2.4 Synthesis of Nanoparticles 45
2.5 Nanoparticle Characterization by Various Instrumental Techniques 50
2.6 Understanding Nanotoxicity: Potential Risks and Implications 53
2.7 Conclusion 54
3 Nanotechnology and Vaccine Development 63 Keshava L. Jetha, Praful D. Bharadia and Manish P. Patel
3.1 Introduction 63
3.2 Overview of Vaccine Development 64
3.3 Advantages of Nanoparticles in Vaccine Delivery 66
3.4 Types of Nanoparticles as Vaccine Carriers 67
3.5 Development of Nanoparticle-Based Vaccine 70
3.6 Adjuvants and their Role in Vaccine Development 72
3.7 Nanoscale Adjuvants 74
3.8 Advantages 75
3.9 Techniques for Nanoscale Adjuvants 76
3.10 Route of Administration for Vaccines 77
3.11 Recent Advances in Nanotechnology-Based Vaccines 79
3.12 The Regulatory Perspective of Nanoparticle-Based Vaccine Development 80
3.13 Future Prospects 81
3.14 Conclusion 84
4 Nanoparticle Formulations: A Sustainable Approach to Biodegradable and Non-Biodegradable Products 95 Amandeep Singh, Shreni Parikh, Nutan Sethi, Sachin Patel, Nrupal Modi and Kaushika Patel
4.1 Introduction 96
4.2 Types of Nanoparticles 96
4.3 Preparation of Nanoparticles 100
4.4 Factors Affecting Selection of Method 100
4.5 Polymers Used in NP Formulation 107
4.6 Nanoparticle Formulations Based on Biodegradable Polymers 107
4.7 Nanoparticle Formulations Based on Non-Biodegradable Polymers 115
4.8 Nanoparticle Formulations Based on Natural Polymers 118
4.9 Challenges in NPs from Laboratory to Industrial Scale-Up 121
5 Nanoparticle Properties: Size, Shape, Charge, Inertness, Efficacy, Morphology 153 Kajal P. Baviskar, Brijesh M. Shah, Anjali P. Bedse, Shilpa S. Raut, Suchita P. Dhamane and Dhara J. Dave
5.1 Introduction 154
5.2 Applications of Nanoparticle Formulations 155
5.3 Interaction with Cells 157
5.4 Properties of Nanoparticles 159
5.5 Role of Physicochemical Properties in Nanoparticle Toxicity 174
5.6 Conclusion 177
Part 2 Nanoparticles to Deliver Antigen 193
6 Viral Vector-Based Nanoparticles 195 Suneetha Vuppu, Vivek P. Chavda, Toshika Mishra, Oishani Sengupta, Anand Sairam, Paridhi Soni, Mohit Joshi, Bhumi Bhalodiya and Raj V.
6.1 Introduction 196
6.2 Characteristics of Viral Vector-Based Nanoparticles 197
6.3 Applications 199
6.4 Novel Advancements in Applications of Viral Nanoparticles 225
6.5 Limitations and Prospects of Viral Vector-Based Nanoparticle Approach 233
