Nanodiamonds in Analytical and Biological Sciences (eBook, ePUB)

Principles and Applications
Redaktion: Hsiao, Wesley Wei-Wen; Le, Trong-Nghia

• Format: ePub

Produktbeschreibung

NANODIAMONDS IN ANALYTICAL AND BIOLOGICAL SCIENCES Comprehensive resource highlighting the significance and applications of fluorescent and non-fluorescent nanodiamonds in various domains Nanodiamonds in Analytical and Biological Sciences combines the disciplines of chemistry, physics, materials science, and biology to demonstrate the significance of nanodiamonds, offering precise analysis of the impacts and up-to-date applications of fluorescent and non-fluorescent nanodiamonds, including in COVID-19 and artificial intelligence, with illustrations, case studies, practical examples, and novel perspectives included throughout. Edited by two highly qualified scholars with significant experience in the field, topics covered include: * Fundamental properties, synthesis, mechanisms, and functionalization of nanodiamonds, and toxicity assessment * Fabrication and surface modification of fluorescent nanodiamonds and in vitro and in vivo bioimaging of fluorescent nanodiamonds * Nanodiamond-enabled drug delivery and nanodiamond for mass spectrometry-based analysis of peptides, proteins, and proteomes * Quantum sensing, applications in physico-chemical and biomedical sensing, and perspective and outlook on the future of nanodiamond research * Nano-scale thermometry of fluorescent nanodiamonds and nanodiamond-enabled drug delivery Offering a balanced, multidisciplinary, and comprehensive overview of the significance of fluorescent and non-fluorescent nanodiamonds, Nanodiamonds in Analytical and Biological Sciences is an essential resource for academic researchers and industry professionals working in fields spanning chemistry, physics, materials science and biology.

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Produktdetails

• Verlag: Wiley-Blackwell
• Seitenzahl: 288
• Erscheinungstermin: 19. September 2023
• Englisch
• ISBN-13: 9781394202157
• Artikelnr.: 69146639

Autorenporträt

Wesley Wei-Wen Hsiao is an Assistant Professor in the Department of Chemical Engineering at the National Taiwan University of Science and Technology. He is former CEO and co-founder of FND Biotech, a company focusing on the development of Fluorescent Nanodiamond (FND)-enabled biotechnologies. Trong-Nghia Le is a postdoctoral researcher at Institute of Atomic and Molecular Sciences, Academia Sinica, under supervision of Professor Huan-Cheng Chang. His research interests include the applications of fluorescent nanodiamonds, biosensing, nanotechnology, polymer science, self-assembly nanoparticles, and targeted drug delivery.

Inhaltsangabe

Contributors xii

Editor's Preface: Nanodiamonds -- A Rising Star in Nanotechnology xv

1 Nanodiamonds 1
Tan-Thanh Huynh, Marvin Chen, Thi-Hong-Hanh Le, Xuan Mai Lam, Kartika Wardhani, and Wesley Wei-Wen Hsiao

1.1 Structure and Classification of Nanodiamonds 1

1.2 Preparation of Nanodiamonds 4

1.2.1 High-Pressure, High-Temperature 5

1.2.2 Detonation Technique 6

1.2.3 Chemical Vapor Deposition 7

1.2.4 Alternative Methods of Producing Nanodiamonds 8

1.3 Physical and Chemical Properties of Nanodiamonds 9

1.4 Colloidal Properties of Nanodiamonds 12

2 Fluorescent Nanodiamonds 19
Wesley Wei-Wen Hsiao, Hsuan-Yi Lin, Ming-Wei Jen, Tan-Thanh Huynh, Thi-Hong-Hanh Le, and Yan-Kai Tzeng

2.1 Introduction to Fluorescent Nanodiamonds 19

2.2 Optical Properties of Fluorescent Nanodiamonds 21

2.2.1 Vacancy-Related Color Centers 22

2.2.2 Negative Nitrogen-Vacancy Center 23

2.2.3 Silicon-Vacancy Center 25

2.3 Introduction to Förster Resonance Energy Transfer 26

2.3.1 Theory 27

2.3.2 FRET Efficiency 28

3 Fabrication of Fluorescent Nanodiamonds 35
Wesley Wei-Wen Hsiao, Jo-Yu Wang, Syun-Ying Wang, Stefanny Angela, and Yan-Kai Tzeng

3.1 Introduction to FND Fabrication 35

3.2 Theoretical Simulations 36

3.3 Production and Characterization of Fluorescent Nanodiamonds 39

3.4 Latest Developments in High-Pressure, High-Temperature Fluorescent Nanodiamonds 41

3.5 Production of Ultrasmall Fluorescent Nanodiamonds 42

3.6 Synthesis of Highly Dispersible Fluorescent Nanodiamonds 45

3.7 Brightly Synthesized Fluorescent Nanodiamonds Using Solar Energy 46

4 Surface Modification of Nanodiamonds 52
Stefanny Angela, Tzu-Chun You, Dinh Minh Pham, Trong-Nghia Le, and Wesley Wei-Wen Hsiao

4.1 Surface Modification of Nanodiamonds 52

4.2 Surface Functionalization of Nanodiamonds 53

4.3 Encapsulation of Nanodiamonds 55

4.4 Bioconjugation of Nanodiamonds 58

4.5 Application of Surface-Modified Nanodiamonds 60

4.5.1 Biotechnological Applications 60

4.5.2 Biomedical Applications 63

5 Toxicity Assessments of Nanodiamonds 73
Duc-Thang Vo, Tzu-Syuan You, Yu-Teng Lin, Stefanny Angela, Trong-Nghia Le, and Wesley Wei-Wen Hsiao

5.1 Cellular Uptake of Fluorescent Nanodiamonds 73

5.2 In vitro Assessments 75

5.3 In vivo Assessments 80

5.4 Nanodiamonds' Phytotoxic Effect 87

5.5 Role of Oxidative Stress in Nanodiamonds' Toxicity 88

6 In vitro Bioimaging of Fluorescent Nanodiamonds 95
Trong-Nghia Le, Yen-Tse Chiang, Yuen Yung Hui, Thi-Hong-Hanh Le, Yan-Kai Tzeng, Neha Sharma, Wei-Hung Chiang, and Wesley Wei-Wen Hsiao

6.1 Bioimaging Applications 95

6.2 Epifluorescence and Confocal Fluorescence Imaging 96

6.3 Single-Particle Tracking 98

6.4 Two-Photon Fluorescence Imaging 102

6.5 Fluorescence Lifetime Imaging 103

6.5.1 Introduction to Fluorescence Lifetime Imaging Microscopy 103

6.5.2 Principles of FLIM 104

6.5.3 Time-Correlated Single-Photon Counting 105

6.5.4 FND for FLIM 105

6.6 Super-Resolution Fluorescence Imaging 108

6.6.1 Introduction to STED Microscopy 108

6.6.2 Principle of STED 109

6.6.3 FND-Enabled STED 111

6.6.4 Combining STED with other Techniques for Bioimaging 113

6.7 Optically Detected Magnetic Resonance Imaging 115

6.8 Cathodoluminescence Imaging 117

6.9 Correlative Light and Electron Microscopy 120
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