Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology (eBook, ePUB)

Redaktion: Grumezescu, Alexandru Mihai

• Format: ePub

Produktbeschreibung

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed.

This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized.

• Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products
• Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years
• Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 696
• Erscheinungstermin: 11. Dezember 2017
• Englisch
• ISBN-13: 9780128136300
• Artikelnr.: 50405725

Inhaltsangabe

1. Fabrication of polymeric core-shell nanostructures 2.
Emulsification-diffusion method to obtain polymeric nanoparticles: two
decades of research 3. Tools and Techniques for the optimized synthesis,
reproducibility and scale up of desired nanostructures from plant derived
material and their role in pharmaceutical properties 4. Scale up of
biopharmaceuticals production 5. Physicochemical and morphological
characterization of pharmaceutical nanocarriers and mathematical modelling
of drug encapsulation/release mass transfer processes 6. Biopharmaceutics
and pharmacokinetics of multifunctional nanoparticles 7. Technological
delivery systems to improve biopharmaceutical properties 8. From
physicochemically stable nanocarriers to targeted drug delivery: in-vivo
pharmacokinetic, pharmacodynamic and biodistribution studies 9. Sterile
dosage forms loaded nanosystems for parenteral, nasal, pulmonary and ocular
administration 10. Quantitative Characterization of Targeted
Nanoparticulate Formulations for Prediction of Clinical Efficacy 11.
Analytical tools for reliable in vitro and in vivo performance testing of
drug nanocrystals 12. Application of one-step affinity purification of
drug-binding proteins with practical magnetic nanoparticles to drug
discovery 13. Molecularly Imprinted Polymers as Separation Tools 14.
Detection of DNA damage induced by nanomaterials 15. Pharmacological usage
of an enzyme inhibitor - a selective inhibitor of 3-mercaptopyruvate
sulfurtransferase reaction intermediate to control generation of
polysulfide 16. Regulatory Consideration in Nanotechnology Based Drug
Products