The combination of clinical and preclinical approaches to understanding nicotine dependence makes this book an invaluable resource for researchers and practitioners seeking to develop targeted treatments aimed at ameliorating symptoms of nicotine dependence, as well as identifying premorbid differences in affective or cognitive function.
- Provides a unique perspective on nicotine dependence that emphasizes negative reinforcement rather than positive reinforcement
- Examines psychiatric comorbidities and alleviation of withdrawal states as motivation for continued tobacco use
- Includes both clinical and preclinical perspectives
- Includes genetic and multi-neurotransmitter perspectives on nicotine use and withdrawal
- Emphasizes heterogeneity of underlying reasons for smoking, the need for multiple animal models to understand this heterogeneity, and the expectation of heterogeneous responses to potential treatments, underscoring the need for personalized therapeutics
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