Neuropsychiatric Disorders and Epigenetics (eBook, ePUB)

Redaktion: Peedicayil, Jacob; Grayson, Dennis R.

• Format: ePub

Produktbeschreibung

Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease.

This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation.

• Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
• Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
• Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding
• Includes chapter contributions from leading global experts

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 480
• Erscheinungstermin: 29. September 2023
• Englisch
• ISBN-13: 9780443185175
• Artikelnr.: 69139764

Inhaltsangabe

Section I. Neuropsychiatric Disorders and Epigenetics: General Aspects
1. Introduction to Neuropsychiatric Disorders and Epigenetics
2. Environmental Factors and Epigenetics of Neuropsychiatric Disorders
3. Epigenetic Biomarkers in Neuropsychiatric Disorders
4. Epigenetics and Neuroimaging in Neuropsychiatric Disorders
5. Recent advances in genome-wide approaches to biomedical research
6. Single Cell Epigenomic Approaches in Neuropsychiatric Disorders
7. Neuropsychiatric Disorders and Epigenetics: Computational Approaches;
Sampling methods; and Power analyses
Section II: Epigenetics of Neuropsychiatric Disorders
8. Epigenetics and Cognitive Disorders -Translational Aspects
9. Epigenetics in Autism Spectrum Disorders - Translational Aspects
10. Epigenetic causes of intellectual disability - the fragile X syndrome
paradigm
11. Epigenetics of Attention-Deficit Hyperactivity Disorder
12. The epigenetics of brain aging and psychiatric disorders
13. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by
downregulating overexpressed chromosome 21 gene products
14. Epigenetics and Multiple Sclerosis
15. Epigenetics and Migraine
16. The role of epigenetics in the pathophysiology of epilepsy
17. Epigenetic Dysregulation in Brain Tumors and Neurodevelopment
18. Epigenetics and Cerebrovascular Diseases
19. Epigenetics of Spinal Muscular Atrophy and the Potential Role of
Epigenetics in the Treatment of this Disorder
20. Epigenetics and Anxiety Disorders
21. Epigenetics and Eating Disorders
22. Epigenetics in Obesity
23. Epigenetics and Drug Addiction-Translational Aspects
24. Epigenetics and Alcohol Use Disorders
Section III: Summary and Outlook
25. Summary and Outlook