New Insights into Glioblastoma (eBook, ePUB)

Diagnosis, Therapeutics and Theranostics
Redaktion: Vitorino, Carla; Cabral, Célia; Balana MD

• Format: ePub

Produktbeschreibung

New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma.

The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment.

• Provides guidance towards recent advances of new chemical entities and delivery strategies targeted to glioblastoma
• Includes overviews to help readers apply information in their research
• Encompasses summarizing diagrams and real-world examples to facilitate comprehension and enhance the applicability of the content

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 786
• Erscheinungstermin: 17. Mai 2023
• Englisch
• ISBN-13: 9780323999427
• Artikelnr.: 68086944

Inhaltsangabe

I. Introduction1 Introduction: A brief outlook into glioblastoma diagnosis
and therapeutics
II. DiagnosisII.1 Biomarkers2. Practice guidelines for the diagnosis of
glioblastoma3. Identification of potential biomarkers in glioblastoma
through OMICS technologies and Big Data Analysis4. Forging a path to the
use of liquid biopsy in the diagnosis of gliomas¿5. Secretome analysis of
patient-derived glioblastoma cells for potential biomarker identification
II.2 Techniques: updates6. Newly diagnosed glioblastoma: a review on
clinical management7. Current status in brain glioma imaging (MRI,
CT-Scan)8. Combined PET/MRI in brain glioma imaging9. New surgical
approaches in glioblastoma10. The role of radiogenomics
III. TherapeuticsIII.1 New chemical entities11. An overview of molecular
targeting of glioblastoma12. Terpenes: a hope for glioblastoma patients13.
The artificial intelligence contribution to speed-up the active compounds
screening14. Repurposing drugs in glioblastoma15. Glioblastoma
heterogeneity and resistance: a glance in biology and therapeutic
approach16. Targeting DNA damage response pathways in glioblastoma: from
mechanistic insights to advances in the clinic17. Alkaloids: their
relevance in cancer treatmentIII.2 New formulation approaches18. An
overview of current drug delivery strategies for glioblastoma treatments
and barriers to progress19. Nanotechnology-based approaches in glioblastoma
treatment: how can the dual blood brain/tumor barriers be overcome?20.
Non-coding RNAs in glioblastoma at a glance21. The role of vaccines in
glioblastoma - updated clinical results22. Dendritic cells and
glioblastoma23. Cancer stem cells in glioblastoma - an update24. Optimizing
the role of immunotherapy for treatment of glioblastoma25. The role of
exosomes in glioblastoma treatment
IV. Theranostics26. Theranostic in glioblastoma27. Potential theranostic
targets in glioblastoma 28. Radiopharmaceuticals for molecular imaging and
theranostics of glioblastoma29. Theranostic strategies synergistically
potentiate glioblastoma treatment via nanotechnology30. The effect of
glioblastoma microenvironment on theranostics