H. M. Colquhoun, J. Holton, D. J. Thompson, M. V. Twigg

New Pathways for Organic Synthesis (eBook, PDF)

Practical Applications of Transition Metals

• Format: PDF

Produktbeschreibung

The continually growing contribution of transition metal chemistry to synthetic organic chemistry is, of course, widely recognized. Equally well known is the difficulty in keeping up-to-date with the multifarious reactions and procedures that seem to be spawned at an ever-increasing rate. These can certainly be summarized on the basis of reviews under the headings of the individual transition metals. More useful to the bench organic chemist, however, would be the opposite type of concordance based on the structural type of the desired synthetic product. This is the approach taken in the present monograph, which presents for each structural entity a conspectus of the transition metal-mediated processes that can be employed in its production. The resulting comparative survey should be a great help in devising the optimum synthetic approach for a particular goal. It is presented from an essentially practical viewpoint, with detailed direc tions interspersed in the Houben-Weyl style. The wide scope of the volume should certainly encourage synthetic organic chemists to utilize fully the range and versatility of these transition metal-mediated processes. This will certainly be a well-thumbed reference book! R. A. RAPHAEL Cambridge University v Preface In recent years an enormous amount of work has been done on the catalysis of organic reactions by various transition metal species and on the organic reactivity of organo-transition-metal compounds.

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 468
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781461326519
• Artikelnr.: 44178986

Inhaltsangabe

1. Introduction.- 2. Formation of Carbon Carbon Bonds.- 2.1. Formation of Carbon Carbon Single Bonds.- 2.1.1. Preparation of Substituted Alkenes.- 2.1.2. Dienes and Polyenes.- 2.1.3. Substituted Alkynes.- 2.1.4. Substituted Arenes.- 2.1.5. Substituted Alkanes (By Conjugate Addition of Organocopper Reagents to Activated Alkenes).- 2.2. Formation of Carbon Carbon Double Bonds.- 2.2.1. Catalytic Alkene Metathesis.- 2.2.2. Dehalogenation of vic-Dihalides and Coupling of gem-Dihalides, Aldehydes, and Ketones.- 2.2.3. Deoxygenation of Epoxides.- 3. Formation of Carbocyclic Compounds.- 3.1. Introduction.- 3.2. Formation of Three-Membered Rings.- 3.2.1. Carbene Addition to Alkenes or Alkynes.- 3.2.2. Cyclization Reactions.- 3.3. Formation of Four-Membered Rings.- 3.3.1. 2?-2? Cycloaddition of Alkenes.- 3.3.2. Cyclization Reactions.- 3.4. Formation of Five-Membered Rings.- 3.4.1. Cycloaddition Reactions Involving Alkenes, Alkynes, and Dienes.- 3.4.2. Cycloaddition of Two Unsaturated Species with a Third Substrate.- 3.4.3. Cyclization of Difunctional Substrates.- 3.5. Formation of Six-Membered Rings.- 3.5.1. Alkyne Trimerization Formation of Aromatic Rings.- 3.5.2. Formation of Nonaromatic Six-Membered Rings from Alkynes.- 3.5.3. Cyclotrimerization of Alkenes and Allenes.- 3.5.4. Cyclodimerization of Dienes and Trienes.- 3.5.5. Cycloaddition of Dienes to Alkenes or Alkynes.- 3.5.6. Cyclization of Difunctional Substrates.- 3.6. Formation of Seven-Membered Rings.- 3.6.1. 3? 4? Cycloaddition Reactions.- 3.6.2. Cyclization of Difunctional Substrates.- 3.7. Formation of Eight-Membered Rings.- 3.7.1. Cyclodimerization of 1,3 Dienes.- 3.7.2. Cyclotetramerization of Alkynes.- 3.8. Formation of Large Rings (?9).- 3.8.1. Cycloaddition Reactions.- 3.8.2. Intramolecular Coupling.- 4. Formation of Heterocyclic Compounds.- 4.1. Introduction.- 4.2. Nitrogen Heterocycles.- 4.2.1. Three-Membered Rings.- 4.2.2. Four-Membered Rings.- 4.2.3. Five-Membered Rings.- 4.2.4. Six-Membered Rings.- 4.2.5. Seven-Membered Rings.- 4.3. Oxygen Heterocycles.- 4.3.1. Five-Membered Rings.- 4.3.2. Six-Membered Rings.- 4.4. Sulfur Heterocycles.- 4.5. Cyclic Compounds Containing Two Hetero Atoms.- 5. Isomerization of Alkenes.- 5.1. Introduction.- 5.2. Thermodynamic Considerations.- 5.3. Isolation of Organometallic Intermediates.- 5.4. Mechanisms of Catalytic Alkene Isomerization.- 5.5. Formation of a,?-Unsaturated Compounds.- 5.5.1. Propenyl Ethers from Allyl Ethers.- 5.5.2. ?,?-Unsaturated Aldehydes and Ketones from Diallyl Ethers.- 5.5.3. Ketones from Allylic Alcohols.- 5.5.4. Enamines from Allylamines.- 5.5.5. Propenylamides from N-Allylamines.- 5.5.6. a,?-Unsaturated Cyclic Ketones via Remote Double-Bond Migration.- 5.5.7. Intercoriversion of a,?-Unsaturated Ketones.- 5.6. Formation of Conjugated Dienes.- 5.7. Migration into Conjugation with Aromatic Rings.- 5.8. Formation of Aromatic Compounds Isoaromatization.- 5.8.1. Formation of Substituted Phenols.- 5.8.2. Formation of Hydroxytropolones.- 5.8.3. Formation of Substituted Anilines.- 6. Direct Introduction and Removal of Carbonyl Groups.- 6.1. Preliminaries.- 6.2. Preparation of Carboxylic Acids, Esters, and Related Derivatives.- 6.2.1. Carboxylic Acids.- 6.2.2. Esters.- 6.2.3. Preparation of Amides.- 6.2.4. Preparation of Anhydrides.- 6.2.5. Preparation of Acyl Halides.- 6.3. Preparation of Aldehydes.- 6.3.1. Aldehydes: From Halides.- 6.3.2. Aldehydes: From Alkenes.- 6.3.3. Aldehydes: From Aldehydes and Silanes.- 6.4. Preparation of Ketones.- 6.4.1. Ketones: From Halides.- 6.4.2. Ketones: From Alkenes and Alkynes.- 6.4.3. Ketones: From Organomercury Compounds.- 6.5. Preparation of Isocyanates.- 6.6. Decarbonylation of Aldehydes and Acyl Halides.- 7. Reduction.- 7.1. Introduction.- 7.1.1. Hydrogenation.- 7.1.2. Transfer Hydrogenation.- 7.1.3. Transition Metal Metal Hydride Reductions.- 7.2. Reduction of Triple Bonds.- 7.2.1. Formation of Alkanes.- 7.2.2. Formation of Alkenes.- 7.2.3. Selective Reductions.- 7.2.4. For