Xiangyu Chen

New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations (eBook, PDF)

• Format: PDF

Produktbeschreibung

This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and a,ß-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of ß-substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging ß-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via ¿-addition. Highly enantiopure tetrahydropyridazinones and ¿-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available a,ß-unsaturated carboxylic acids were first successfully employed to generate the a,ß-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.

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Produktdetails

• Verlag: Springer Nature Singapore
• Seitenzahl: 123
• Erscheinungstermin: 20. Dezember 2016
• Englisch
• ISBN-13: 9789811028991
• Artikelnr.: 53034760

Inhaltsangabe

Introduction.- NHC-catalyzed Annulations of Nitroalkenes.- NHC-catalyzed Enantioselective Annulations of Enals.- NHC-catalyzed Enantioselective Annulations of ,beta-unsaturated Carboxylic Acids.- Experimental Part.- Research Summary.