Nitrosoureas (eBook, PDF)

Current Status and New Developments
Redaktion: Prestayko, Archie W.; Crooke, Stanley T.; Baker, Laurence H.

• Format: PDF

Produktbeschreibung

Nitrosoureas: Current Status and New Developments covers the preclinical and clinical status of nitrosoureas. The book presents preclinical studies on the development of the nitrosoureas; combination chemotherapy with nitrosoureas plus other anticancer drugs against animal tumors; EORTC studies with novel nitrosoureas; and chemical decomposition of chloroethylnitrosoureas.
The text also includes preclinical studies on the metabolism of nitrosoureas; DNA crosslinking and the origin of sensitivity to chloroethylnitrosoureas; modification of DNA and RNA bases; and carbamoylating activity of nitrosoureas. Clinical studies on subacute and chronic toxicities associated with nitrosourea therapy; the toxicity of high-dose BCNU with autologous marrow support; and the clinical pharmacology of the nitrosoureas are also considered. The book further tackles clinical studies on nitrosoureas in the therapy of Hodgkin's disease; nitrosourea-containing combinations in small-cell lung cancer; adjuvant therapy of brain tumors with nitrosoureas; and clinical use of nitrosoureas in gastrointestinal cancer.
Oncologists, toxicologists, biochemists, pharmacologists, and other scientists working in drug development will find the text invaluable.

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 436
• Erscheinungstermin: 22. Oktober 2013
• Englisch
• ISBN-13: 9781483219448
• Artikelnr.: 41873269