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Written by the pioneers who have energized the research, Nucleotides and Regulation of Bone Cell Function covers all aspects of purinergic signaling with regard to osteoblasts, osteoclasts, and chondrocytes, providing an exploration into how nucleotides act on skeletal cells. It reveals the distribution of receptors for purines and pyrimidines in both neuronal and non-neuronal cells, considers purinergic and P2 nucleotide receptor signaling in osteoclasts, and examines the role of signaling in regulating cartilage metabolism and chondrocyte function. It also considers the pathophysiologic implications of the findings, and discusses the potential of purine-related therapies for a variety of diseases.
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