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The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary…mehr
The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.
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Mihai D. Niculescu is an Assistant Professor of Nutrition at the University of North Carolina's Gillings School of Global Public Health in Chapel Hill, and at the UNC Nutrition Research Institute in Kannapolis, North Carolina, USA. Paul Haggarty is Head of the Lifelong Health Programme, and the Nutrition and Epigenetics Group, at the Rowett Institute of Nutrition and Health in the University of Aberdeen in Aberdeen, Scotland.
Inhaltsangabe
Contributors vii 1. Introduction 1 Mihai D. Niculescu and Paul Haggarty Part I: Fundamental Principles in Epigenetics Section A: Epigenetic Mechanisms 2. DNA Methylation 13 Natalia V. Cucu 3. Chromatin Modifications 47 Sandra B. Hake 4. Roles of RNAi and Other Micro-RNAs in the Regulation of Epigenetic Processes 73 Muller Fabbri 5. Epigenetic Inheritance: Both Mitotic and Meiotic 87 Nina J. Kaminen-Ahola, Arttu I. Ahola, and Emma Whitelaw Section B: Development Epigenetics 6. Developmental Epigenetics: Roles in Embryonic Development 107 Liliana Burlibas¿a and Lucian Gavrila Section C: Epigenetic Mechanisms in Disease 7. Epigenetics, Nutrition, and Cancer 129 Amy R. Johnson 8. Metabolic Syndrome, Obesity, and Diabetes 145 Karen D. Corbin 9. Autoimmunity 165 Donna Ray and Raymond Yung 10. Cardiovascular Diseases 173 Aurelian Bidulescu and Methode Bacanamwo Part II: Nutritional Status and Specific Nutrients Section A: Maternal Nutrition and Fetal Development 11. Maternal Nutrition and Developmental Outcomes 193 Shannon L. Haley, Laurie J. Moyer-Mileur, Robert H. Lane, and Lisa A. Joss-Moore Section B: Role of Specific Nutrients 12. Folate, Vitamin B12, and Vitamin B6 211 Patrick J. Stover 13. Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing Brain Development 225 Steven H. Zeisel 14. Epigenetic Regulation by Retinoids 241 Amandio Vieira 15. We Are What We Eat: How Nutritional Compounds Such As Isoflavones Shape Our Epigenome 249 Carlos M. Guerrero-Bosagna and Susan J. Clark 16. Isothiocyanates and Polyphenols 263 Nigel J. Belshaw and Ian T. Johnson Section C: Macronutrient Intakes 17. The Effect of Maternal Macronutrient Intake on Phenotype Induction and Epigenetic Gene Regulation 275 Karen A. Lillycrop, Mark A. Hanson, and Graham C. Burdge Section D: Environmental Exposures 18. Epigenetic Manifestation of Environmental Exposures 289 Dana C. Dolinoy, Olivia S. Anderson, and Laura S. Rozek Section E: Epidemiology of Nutritional Epigenetics 19. Epigenetics, Nutrition, and Reproduction: Short- and Long-Term Consequences 311 Paul Haggarty 20. Nutrition, Epigenetics, and Cancer: An Epidemiological Perspective 329 Audrey Jung and Ellen Kampman Index 345
Contributors vii 1. Introduction 1 Mihai D. Niculescu and Paul Haggarty Part I: Fundamental Principles in Epigenetics Section A: Epigenetic Mechanisms 2. DNA Methylation 13 Natalia V. Cucu 3. Chromatin Modifications 47 Sandra B. Hake 4. Roles of RNAi and Other Micro-RNAs in the Regulation of Epigenetic Processes 73 Muller Fabbri 5. Epigenetic Inheritance: Both Mitotic and Meiotic 87 Nina J. Kaminen-Ahola, Arttu I. Ahola, and Emma Whitelaw Section B: Development Epigenetics 6. Developmental Epigenetics: Roles in Embryonic Development 107 Liliana Burlibas¿a and Lucian Gavrila Section C: Epigenetic Mechanisms in Disease 7. Epigenetics, Nutrition, and Cancer 129 Amy R. Johnson 8. Metabolic Syndrome, Obesity, and Diabetes 145 Karen D. Corbin 9. Autoimmunity 165 Donna Ray and Raymond Yung 10. Cardiovascular Diseases 173 Aurelian Bidulescu and Methode Bacanamwo Part II: Nutritional Status and Specific Nutrients Section A: Maternal Nutrition and Fetal Development 11. Maternal Nutrition and Developmental Outcomes 193 Shannon L. Haley, Laurie J. Moyer-Mileur, Robert H. Lane, and Lisa A. Joss-Moore Section B: Role of Specific Nutrients 12. Folate, Vitamin B12, and Vitamin B6 211 Patrick J. Stover 13. Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing Brain Development 225 Steven H. Zeisel 14. Epigenetic Regulation by Retinoids 241 Amandio Vieira 15. We Are What We Eat: How Nutritional Compounds Such As Isoflavones Shape Our Epigenome 249 Carlos M. Guerrero-Bosagna and Susan J. Clark 16. Isothiocyanates and Polyphenols 263 Nigel J. Belshaw and Ian T. Johnson Section C: Macronutrient Intakes 17. The Effect of Maternal Macronutrient Intake on Phenotype Induction and Epigenetic Gene Regulation 275 Karen A. Lillycrop, Mark A. Hanson, and Graham C. Burdge Section D: Environmental Exposures 18. Epigenetic Manifestation of Environmental Exposures 289 Dana C. Dolinoy, Olivia S. Anderson, and Laura S. Rozek Section E: Epidemiology of Nutritional Epigenetics 19. Epigenetics, Nutrition, and Reproduction: Short- and Long-Term Consequences 311 Paul Haggarty 20. Nutrition, Epigenetics, and Cancer: An Epidemiological Perspective 329 Audrey Jung and Ellen Kampman Index 345
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