Obesity Before Birth (eBook, PDF)

Maternal and prenatal influences on the offspring
Redaktion: Lustig, Robert H

• Format: PDF

Produktbeschreibung

Obesity obeys the First Law of Thermodynamics. The routine assumption is that obesity is the result of a mismatch between calories in and calories out; in other words, the result of two divergent behaviors. However, there is mounting evidence that biochemical forces can drive obligate weight gain, and that the observed behaviors of increased energy intake and decreased energy expenditure are secondary to these processes. Furthermore, many of these biochemical forces are determined in utero; resulting in a developmental drive toward obesity and disease in later life. Four distinct prenatal forces have thus far been identified: 1) genetics; 2) epigenetics; 3) developmental programming; and 4) environmental obesogens. This volume explores the evidence for each of these in detail in human and animal models, and attempts to provide a cohesive analysis of the biochemical bases of obesity. This volume will appeal to geneticists, developmental biologists, endocrinologists, epidemiologists, toxicologists, obstetrician/gynecologists, nutritionists, veterinary scientists, animal husbandry researchers, domestic species researchers, and obesity researchers and practitioners. "This very timely volume provides an in-depth scholarly overview of a critical challenge facing our society-the obesity epidemic. Dr. Robert H. Lustig has assembled expert authors to address the fundamental contribution of preprogrammed genetic disorders leading to obesity, as well as the role of very early environmental influences. The chapters range from classic genetic mechanistic understanding through intra-uterine epigenetic influences, factors determining developmental programming, and the new clinical science of perinatal obesogens. Obesity Before Birth: Maternal and prenatal influences on the offspring, brings easily accessible, cutting edge information to geneticists, pediatricians, endocrinologists, as well as those clinicians and scientists pursuing the complex yet elusive causes ofchildhood obesity and related disorders." - Shlomo Melmed, M.D. Series Editor

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Springer US
• Seitenzahl: 414
• Erscheinungstermin: 23. September 2010
• Englisch
• ISBN-13: 9781441970343
• Artikelnr.: 37361823

Inhaltsangabe

From the contents:
Preface
Obesity: nature or nurture?
The contribution of heredity to clinical obesity
Monogenetic disorders within the energy balance pathway
Ciliary syndromes and obesity
Genome-wide association studies and human population obesity
Known clinical epigenetic disorders with an obesity phenotype: Prader-Willi Syndrome and the GNAS locus
Evidence for epigenetic changes as a cause of clinical obesity
Epigenetic changes associated with intrauterine growth retardation and adipogenesis
Exposure to diabetes in utero, offspring growth, and risk for obesity
Maternal weight gain during pregnancy and obesity in the offspring
Intrauterine growth restriction, small for gestational age, and experimental obesity
Experimental models of maternal obesity and high-fat diet during pregnancy and programmed obesity in the offspring
High carbohydrate intake only during the suckling period results in adult-onset obesity in mother as well as offspring
Prenatal stress, glucocorticoids, and the metabolic syndrome
Hypothalamic maldevelopment and developmental programming
Adipocyte development and experimental obesity
The obesogen hypothesis of obesity: overview and human evidence
Perinatal exposure to endocrine disrupting chemicals with estrogenic activity and the development of obesity
The role of environmental obesogens in the obesity epidemic.

Rezensionen

From the reviews:

"An interesting and timely book. ... For obstetricians, neonatologists and pediatricians in general. Recommended." (Pediatric Endocrinology Reviews (PER), Vol. 9 (2), December, 2011)