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This book is a comprehensive guide to occupational factors of malignant diseases. It discusses potentially work-related malignancies, in the context of exposure assessment, specific clinical and pathological features of occupational cancer and biomarkers of exposure and disease. Epidemiological data about risk ratios of the cancer in question are reviewed for various occupations and with exposure to specific carcinogens, carcinogenic mechanisms, host susceptibility factors (genetic and other) and other environmental and life-style risk factors. Aspects such as surveillance of workers exposed…mehr
This book is a comprehensive guide to occupational factors of malignant diseases. It discusses potentially work-related malignancies, in the context of exposure assessment, specific clinical and pathological features of occupational cancer and biomarkers of exposure and disease. Epidemiological data about risk ratios of the cancer in question are reviewed for various occupations and with exposure to specific carcinogens, carcinogenic mechanisms, host susceptibility factors (genetic and other) and other environmental and life-style risk factors. Aspects such as surveillance of workers exposed to carcinogens, and strategies for prevention of occupational cancer are also discussed.
Occupational Cancers is aimed at oncologists, pathologists, residents in training, clinical researchers, clinicians in occupational health, epidemiologists, pulmonologists, lawyers and public health officials.
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Autorenporträt
Paolo Boffetta, MD, MPHBluhdorn Professor of International Community MedicineDirector, Institute for Translational EpidemiologyAssociate Director for Population Sciences, Tisch Cancer InstituteIcahn School of Medicine at Mount SinaiOne Gustave L. Levy PlaceNew York, NY, USASisko Anttila MD, PhDHelsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Laboratory Services, HUSLAB, andFinnish Institute of Occupational Health, Helsinki, Finland.
Inhaltsangabe
Foreword [Harri Vainio]Chapter 1 Environmental and occupational factors of cancer [PB, SA]This chapter contains general information that assists understanding of the rest of the book, such as - interpretation of epidemiological evidence and terminology - classification of carcinogenic agents and factors - introduction to molecular mechanisms of carcinogenesis - host susceptibility factors, genetic and acquired (life-style and environment) - biomarkers of exposure and disease; applications in research and practice - means of prevention of occupational cancer Chapter 2 Historical overview of occupational cancer research and control [Jack Siemiatycki]Chapter 3 Occupational cancer burden [PB]Contains epidemiological data from Western as well as low- and medium-resource countries Chapter 4 Genetics and gene-environment interactions [Karl T. Kelsey]Chapter 5 Mechanisms of carcinogenesis [SA, Karl T. Kelsey]Chapters 6-23 6-23 Organ-specific chapters contain organized data (see example of lung cancer below) about occupational factors of specific cancers. Often the same chemical or physical agents may be occupational or related to life-style or environmental factors. Exposures other than occupational may have synergistic effect on the cancer risk and are important to discuss. Cancer sites and examples of occupational risk factors are listed below. Main chapters would include: Cancer of the oral cavity, pharynx and nasopharynx [Daniele Luce]- risk factors : formaldehyde, wood dust, chlorophenols, pesticides, chromates, nickel, arsenic, welding fumes, textile dust, HPV, tobacco etc. Cancers of the gastrointestinal tract [Farhad Islami, Farin Kamangar]- Oesophagus (adenocarcinoma): asbestos, cement dust, pesticides, acetaldehyde - Cardia (adenocarcinoma): asphalt fumes, wood dust, pesticides - Gastric cancer: cement dust, quartz, diesel exhaust, coal and tin mining, metal processing, rubber manufacturing, N-nitroso compounds etc. Malignant tumours of the liver [Amr Soliman]- occupational risk factors: vinyl chloride and polyvinyl chloride, solvents, chlorinated hydrocarbons, arsenic - other risk factors: hepatitis infection, aflatoxin, ethanol - Angiosarcoma of the liver: vinyl chloride Pancreatic cancer [Eric Duell]- occupational risk factors not known - others: tobacco, ethanol Sinonasal cancer [Daniele Luce]- risk factors depending on histological type: formaldehyde, wood dust, chlorophenols, pesticides, chromates, nickel, arsenic, welding fumes, textile dust, HPV, tobacco etc. Laryngeal cancer [PB]- PAH, combustion products, diesel fumes, wood dust, viruses, asbestos, alcohol, tobacco etc. Lung cancer [PB, SA, for silica/asbestos-related LC in addition Douglas Henderson or Victor Roggli]- asbestos, silica, PAH, arsenic, chromates etc. Malignant tumours of bone and soft tissues [contributors to be decided later]- Bone sarcomas: several risk factors like pesticides, woodworking, metal working suspected - Soft tissue sarcomas: pesticides, chlorophenols, dioxin etc., suspected Malignant tumours of the skin [Philippe Autier]- risk factors: UV light, PAH, coal-tar, arsenic, viruses, radon etc. - Mycosis fungoides: halogenated aromatic hydrocarbons/pesticides, UVR, infections Malignant mesothelioma [Antti Tossavainen, Francoise Galateau-Salle]- asbestos Breast cancer [Elisabete Weiderpass]- occupational and other environmental risk factors: shift-work, possibly DDT before puberty - others: HRT Malignant tumours of the female reproductive system [Elisabete Weiderpass]- occupational risk factors not known - others: smoking, HRT, HPV Malignant tumours of the male reproductive system [Lorenzo Richiardi]- Prostate cancer: possible occupational risk factors pesticides, PAH, metal working fluids/mineral oils - Testicular cancer: occupational risk factors not known Kidney cancer [Ghislaine Scelo]- occupational risk factors: arsenic, cadmium, lead, solvents - others: smoking, environmental tobacco smoke Bladder
Foreword [Harri Vainio]Chapter 1 Environmental and occupational factors of cancer [PB, SA]This chapter contains general information that assists understanding of the rest of the book, such as - interpretation of epidemiological evidence and terminology - classification of carcinogenic agents and factors - introduction to molecular mechanisms of carcinogenesis - host susceptibility factors, genetic and acquired (life-style and environment) - biomarkers of exposure and disease; applications in research and practice - means of prevention of occupational cancer Chapter 2 Historical overview of occupational cancer research and control [Jack Siemiatycki]Chapter 3 Occupational cancer burden [PB]Contains epidemiological data from Western as well as low- and medium-resource countries Chapter 4 Genetics and gene-environment interactions [Karl T. Kelsey]Chapter 5 Mechanisms of carcinogenesis [SA, Karl T. Kelsey]Chapters 6-23 6-23 Organ-specific chapters contain organized data (see example of lung cancer below) about occupational factors of specific cancers. Often the same chemical or physical agents may be occupational or related to life-style or environmental factors. Exposures other than occupational may have synergistic effect on the cancer risk and are important to discuss. Cancer sites and examples of occupational risk factors are listed below. Main chapters would include: Cancer of the oral cavity, pharynx and nasopharynx [Daniele Luce]- risk factors : formaldehyde, wood dust, chlorophenols, pesticides, chromates, nickel, arsenic, welding fumes, textile dust, HPV, tobacco etc. Cancers of the gastrointestinal tract [Farhad Islami, Farin Kamangar]- Oesophagus (adenocarcinoma): asbestos, cement dust, pesticides, acetaldehyde - Cardia (adenocarcinoma): asphalt fumes, wood dust, pesticides - Gastric cancer: cement dust, quartz, diesel exhaust, coal and tin mining, metal processing, rubber manufacturing, N-nitroso compounds etc. Malignant tumours of the liver [Amr Soliman]- occupational risk factors: vinyl chloride and polyvinyl chloride, solvents, chlorinated hydrocarbons, arsenic - other risk factors: hepatitis infection, aflatoxin, ethanol - Angiosarcoma of the liver: vinyl chloride Pancreatic cancer [Eric Duell]- occupational risk factors not known - others: tobacco, ethanol Sinonasal cancer [Daniele Luce]- risk factors depending on histological type: formaldehyde, wood dust, chlorophenols, pesticides, chromates, nickel, arsenic, welding fumes, textile dust, HPV, tobacco etc. Laryngeal cancer [PB]- PAH, combustion products, diesel fumes, wood dust, viruses, asbestos, alcohol, tobacco etc. Lung cancer [PB, SA, for silica/asbestos-related LC in addition Douglas Henderson or Victor Roggli]- asbestos, silica, PAH, arsenic, chromates etc. Malignant tumours of bone and soft tissues [contributors to be decided later]- Bone sarcomas: several risk factors like pesticides, woodworking, metal working suspected - Soft tissue sarcomas: pesticides, chlorophenols, dioxin etc., suspected Malignant tumours of the skin [Philippe Autier]- risk factors: UV light, PAH, coal-tar, arsenic, viruses, radon etc. - Mycosis fungoides: halogenated aromatic hydrocarbons/pesticides, UVR, infections Malignant mesothelioma [Antti Tossavainen, Francoise Galateau-Salle]- asbestos Breast cancer [Elisabete Weiderpass]- occupational and other environmental risk factors: shift-work, possibly DDT before puberty - others: HRT Malignant tumours of the female reproductive system [Elisabete Weiderpass]- occupational risk factors not known - others: smoking, HRT, HPV Malignant tumours of the male reproductive system [Lorenzo Richiardi]- Prostate cancer: possible occupational risk factors pesticides, PAH, metal working fluids/mineral oils - Testicular cancer: occupational risk factors not known Kidney cancer [Ghislaine Scelo]- occupational risk factors: arsenic, cadmium, lead, solvents - others: smoking, environmental tobacco smoke Bladder
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